Control of Mitochondrial Transcription Specificity Factors (TFB1M and TFB2M) by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators

By Natalie Gleyzer, K. Vercauteren, R. Scarpulla. Molecular and Cellular Biology, 2005

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Oxidant Mechanisms in Renal Injury and Disease (2016, positive): “In addition, ROS induced stimulation of NRF-1 promotes activation of mitochondrial transcription factor A (Tfam) and stimulation of mitochondrial DNA replication/transcription and biogenesis (93,326), effects aimed at preventing tissue damage.”
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “This contrasts with the human Tfam (224) and TFB (73) promoters, which rely on both NRF-1 and NRF-2 for their activities (Fig.”
The Molecular Bases of Training Adaptation (2007, background): “2004) while NRF-1 and NRF-2 are implicated in the transcriptional control of multiple mitochondrial genes including mitochondrial transcription factor A (Tfam) and recently identified mitochondrial transcription specificity factors TFB1M and TFB2M (Scarpulla 2002; Gleyzer et al. 2005).”
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network (2010, background): “Serum induction of PRC is associated with a gene expression profile that is similar to that observed in response to elevated PGC-1α [91,94].”
Regulation of energy metabolism by long-chain fatty acids. (2014, background): “A functional ERRa binding site is identified in the promoter of ERRa gene [157], whereas PGC1a increased NRF1,2 mRNA in C2C12 myotube cells [161].”