The regulation of protein function by multisite phosphorylation--a 25 year update.

By P. Cohen. TIBS -Trends in Biochemical Sciences. Regular ed, 2000

1,117 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1ceed6304cfe581cd26d97d6a8d60ee6dbd3d912

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Citations in the corpus

Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. (2014, result): “Therefore, in contrast to commonly cited estimates that were based on in situ radiolabeling and 2D electrophoresis (Cohen, 2000; Pinna and Ruzzene, 1996), at least three-quarters of the expressed proteome can be phosphorylated.”
PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites (2007, background): “Rationale Protein phosphorylation is a ubiquitous and important posttranslational modification, responsible for modulating protein function, localization, interaction and stability [1-4].”
The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors (2016, positive): “Protein modifications include processes such as acetylation [8], methylation [9], or phosphorylation [10].”
Proteomic analysis of post-translational modifications (2003, background): “In signaling, for example, kinase cascades are turned on and off by the reversible addition and removal of phosphate group”
Mechanisms of specificity in protein phosphorylation (2007, background): “Furthermore, it has been estimated that 30% of all cellular proteins are phosphorylated on at least one residu”
Phosphorylation: Implications in Cancer (2017, background): “The first phosphoprotein discovered was glycogen phosphorylase, however, later it was reported that there are thousands of distinct phosphorylation sites and around 30% of all proteins may be phosphorylated in eukaryotes [6].”
Prediction of human protein function from post-translational modifications and localization features. (2002, background): “It is very satisfying that this correlation was found by the neural networks when considering that reversible phosphorylation is a well known and widely used regulatory mechanism.(20) Glycosylation was also found to be a strong indicator for regulatory proteins.”
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication (2001, background): “Phosphorylation on multiple residues may help enable events such as multisite docking interactions, integration of different kinase pathways, substrate dephosphorylation, subcellular localization, and protein activit”