Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

By Junying Yu, M. Vodyanik, K. Smuga-Otto, Jessica Antosiewicz-Bourget, Jennifer L. Frane, Shulan Tian, Jeff Nie, Gudrun A. Jonsdottir, Victor Ruotti, Ron M. Stewart and 2 more. 2007

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Subfields: Molecular Biology

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Citations in the corpus

The promise of induced pluripotent stem cells in research and therapy (2012, background): “This historic contribution inspired an astonishing flurry of follow-up studies, with successful reprogramming quickly translated to human fibroblast”
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells (2008, positive): “Notably, ectopic expression of Lin28 in human fibroblasts promotes the induction of pluripotency (Yu et al., 2007), suggesting that blocked maturation of pri-Let-7 transcripts plays an important role in the pluripotent state.”
A Small Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog (2009, background): “, 2003) and has been shown to enhance the efficiency of reprogramming (Silva et al., 2006; Silva et al., 2009; Yu et al., 2007), we decided to test whether Nanog could directly replace Sox2 in reprogramming.”
Oct4-induced pluripotency in adult neural stem cells. (2009, neutral): “…(Oct4, Sox2, Klf4, and c-Myc) from mouse and human somatic cells (Lowry et al., 2008; Maherali et al., 2007; Meissner et al., 2007; Okita et al., 2007, 2008; Park et al., 2008; Stadtfeld et al., 2008; Takahashi et al., 2007; Takahashi and Yamanaka, 2006; Wernig et al., 2007; Yu et al., 2007).”
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. (2008, background): “It has been shown recently that retroviral transduction of mouse and human somatic cells with four transcription factors initiates the gradual conversion of a small subpopulation of the infected cells into a pluripotent, ES cell-like state (Maherali et al., 2007; Meissner et al., 2007; Okita et al.,”
Metazoan MicroRNAs (2018, background): “Highlighting the potential biological relevance of this pathway, the let-7 miRNAs promote cellular differentiation (Melton et al., 2010), and Lin28 is one of the factors that can help reverse this differentiation during induction of pluripotent stem cells (Yu et al., 2007).”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “In addition, an expression analysis of 217 Oncogene Table 1 miRNAs with relevance in cancer and cell death miRNA Normal function Cancer relevance Cell death relevance Targets References Let-7/miR-98 Upregulated late during Caenorhabditis elegans development; increased expression in differentiated ce”
A fresh look at iPS cells. (2009, background): “In 2007, germline transmission was achieved with mouse iPS cells (Meissner et al., 2007; Okita et al., 2007; Wernig et al., 2007), and iPS cells were generated from human fibroblasts (Park et al., 2008b; Takahashi et al., 2007; Yu et al., 2007).”
Functional Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells (2009, neutral): “H9 (4) Foreskin C1 (3) IMR90 C4 (5) 50 100 * * *”