Most Early Disseminated Cancer Cells Detected in Bone Marrow of Breast Cancer Patients Have a Putative Breast Cancer Stem Cell Phenotype

By M. Balić, Henry K. Lin, L. Young, D. Hawes, A. Giuliano, G. McNamara, R. Datar, R. Cote. Clinical Cancer Research, 2006

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EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “Thus, DTCs detected in the bone marrow of breast cancer patients exhibit features of CSCs (Balic et al., 2006).”
The cancer stem cell: premises, promises and challenges (2011, background): “Along these lines, tumorigenic CD44 + CD24 −/low cells are readily detectable in metastatic pleural fluid in subjects with breast cancer; in addition, breast cancer cells found in bone marrow show a putative breast CSC phenotyp”
Models, mechanisms and clinical evidence for cancer dormancy (2007, background): “However, only a few studies have looked at stem cell markers and it is not clear if these serve as prognostic indicator”
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, background): “In patients with breast cancer, tumorigenic CD44 + CD24 −/low cells are readily detectable in metastatic pleural effusions, and most early-disseminated cancer cells that are detected in the bone marrow have a putative breast tumour-initiating cell phenotyp”
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients (2009, background): “In this regard, one study confirmed a putative stem cell phenotype in disseminated tumor cells (DTCs) [11], and another study showed that the majority of early DTCs detected in the bone marrow of breast cancer patients with a CD44+/CD24-”