Impact of Basic Research On Tomorrow's MedicineProinflammatory Cytokines

By C. A. Dinarello. 2000

2,123 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1b7bf9d04ad013e674dc5f232a21bfe69f5288a9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Kunal Rehani
2. M. Keel
3. Michael Martin
4. M. Bianchi
5. S. Michalek
6. A. Vezzani
7. T. Granata
8. O. Trentz

In Molecular Biology

1. A. Rubartelli
2. Kunal Rehani
3. M. Keel
4. Michael Martin
5. M. Bianchi
6. S. Michalek
7. A. Vezzani
8. T. Granata

Citations in the corpus

• The nuclear protein HMGB1 is secreted by monocytes via a non‐classical, vesicle‐mediated secretory pathway (2002, background): “The microenvironment is important in the modulation of the inflammatory response, which is finely tuned by soluble factors such as ATP and cytokines, osmolarity, bioactive lipids and cell–cell interactions (Andrei et al., 1999; Dart and Chin-Dusting, 1999; Andrews, 2000; Dinarello, 2000).”
• Pathophysiology of polytrauma. (2005, positive): “They are capable of exerting many effects on an array of cell types (pleiotropy).(40) Besides hyperacute pro-inflammatory cytokines, such as tumor necrosis factor-a (TNF-a), or interleukin-1b (IL-1b), with an effect after 1—2 h, there exist subacute (secondary) cytokines such as IL-6, IL-8 (neutroph”
• Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3 (2005, positive): “RESULTS TLR4-mediated phosphorylation of GSK3-b PI(3)K is a heterodimeric enzyme that consists of a regulatory subunit (p85) and a catalytic subunit (p110)10.”
• Brain Inflammation in Epilepsy: Experimental and Clinical Evidence (2005, background): “Production of proinflammatory molecules [cytokines inducing a portfolio of genes that are established mediators of inflammation (43)] is typically accompanied by the concomitant synthesis of antiinflammatory mediators and binding proteins apt to modulate the inflammatory response, thus avoiding the ”
• The effects of acute psychological stress on circulating and stimulated inflammatory markers: A systematic review and meta-analysis (2017, background): “Locally, cytokines are regulated by their short half-lives (range 1-4 hours), the presence of receptor antagonists, and the production of anti-inflammatory cytokines (e.g. IL-10 and IL-4; Dinarello, 2000; Roitt & Delves, 2001).”