Brain Inflammation in Epilepsy: Experimental and Clinical Evidence

By A. Vezzani, T. Granata. Epilepsia, 2005

1,059 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/77ac6890236b5d8319c0be1ac4f7320245a8076a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. L. Mucke
2. J. Palop
3. Eleonora Aronica
4. A. Vezzani

In Physiology

1. L. Mucke
2. J. Palop
3. Eleonora Aronica
4. D. Selkoe

In Psychiatry and Mental health

1. L. Mucke
2. J. Palop
3. Eleonora Aronica
4. Alberto E. Musto
5. Amna Rana
6. A. Vezzani

Citations in the corpus

• Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures (2010, background): “Increasing evidence supports the involvement of inflammatory and immune processes in the etiopathogenesis of seizure”
• Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. (2007, positive): “…Klatzo, 1983; Oztas and Kaya, 1991), free radical formation (Oztas et al., 2001), inflammatory responses such as leucocyte recruitment, cytokine and interleukin production (Patel, 2004; Vezzani and Granata, 2005; Gorter et al., 2006) and/or loss of tight junction molecules (Ballabh et al., 2004).”
• Amyloid-β Induced Neuronal Dysfunction in Alzheimer’s Disease: From Synapses toward Neural Networks (2010, background): “In addition, activated microglia in Alzheimer's disease generate inflammatory mediators, such as cytokines, that can enhance neuronal excitabilit”
• The role of inflammation in the development of epilepsy (2018, background): “Epileptogenesis and aberrant plasticity associated with epilepsy are attenuated by PAF receptor antagonists [7, 50].”
• Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. (2008, background): “Functional studies in rodents demonstrate that cytokines (for review see Jankowsky and Patterson, 2001; Vezzani and Granata, 2005) such as IL-1β and TNF-α, alter neuronal excitability and the generation of seizures and may contribute to neuronal cell loss, astrogliosis and BBB damage (Vezzani et…”