Lipotoxic heart disease in obese rats: implications for human obesity.

By Y. Zhou, Paul A. Grayburn, Asad Karim, M. Shimabukuro, M. Higa, D. Baetens, L. Orci, R. Unger. Proceedings of the National Academy of Sciences of the United States of America, 2000

1,332 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/1b2ea677c0d3845a7bd59988b582af869416b3d4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. M. Hill
2. Guanghong Jia
3. J. Sowers
4. E. Dale Abel

In Molecular Biology

1. M. Hill
2. Guanghong Jia
3. J. Sowers
4. E. Dale Abel
5. Andrej Shevchenko
6. Douglas P Lee
7. S. Summers
8. William L. Holland

In Physiology

1. M. Hill
2. S. Summers
3. William L. Holland
4. Guanghong Jia
5. J. Sowers
6. H. Fang
7. R. L. Judd
8. Barry J. Goldstein

Citations in the corpus

• Mechanisms linking obesity with cardiovascular disease (2006, background): “In animal models, cardiac lipotoxicity causes eccentric left ventricular remodelling, increased left ventricular pressure and decreased systolic performanc”
• A novel mouse model of lipotoxic cardiomyopathy. (2001, background): “In the ZDF rat, triglyceride accumulation is associated with DNA laddering, suggesting that excess tissue fatty acids induce programmed cell death and lead to heart failure (18).”
• Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity (2018, background): “In rodent cardiomyocytes, this was shown to further decrease cardiac function by inhibition of FFA oxidation and increased intracellular fat accumulation.(112,113) However, human studies suggest that PPAR-α expression is not significantly altered in the hearts of patients with type 2 diabetes mellit”
• Association between insulin resistance and the development of cardiovascular disease (2018, background): “This shift induces an increase in the uptake and accumulation of lipid in the heart, producing lipotoxicity [80].”
• Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart (2004, background): “Because treatment of the ZDF rat with insulin-sensitizing drugs removes intramyocardial triglyceride deposits and improves contractile function (2, 4), we propose that similar improvement in the coupling between fatty acid delivery and oxidation in the lipid overloaded failing heart may improve card”
• Molecular mechanisms of diabetic cardiomyopathy (2014, neutral): “Finally, increased ceramide levels can also activate inflammatory signalling pathways and increase reactive nitrogen species [83].”
• Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. (2008, background): “Lipid accumulation in the heart is associated with impaired contractile function (166, 274).”