The world of subinhibitory antibiotic concentrations.

By J. Davies, G. Spiegelman, Grace Yim. Current Opinion in Microbiology, 2006

731 citations recorded by the source corpus.

Subfields: Genetics, Microbiology, Pollution

View Paper: https://www.semanticscholar.org/paper/1b106ec59a423fe3461c7566f12e65e869234faf

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In Genetics

1. James J. Collins
2. K. Allison
3. Ahmad S. Khalil
4. R. Aminov
5. A. Decho
6. Jo Handelsman
7. H. Stokes
8. M. Gillings

In Microbiology

1. R. Aminov
2. A. Decho
3. James J. Collins
4. T. Gutierrez

In Pollution

1. R. Aminov
2. T. Gutierrez
3. D. Fatta-Kassinos
4. H. Stokes
5. M. Gillings
6. H. Flemming
7. G. Underwood

Citations in the corpus

• Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens. (2011, background): “We know that antimicrobial compounds induce stress in bacterial cells, leading to changes in transcriptomic profiles (Davies et al., 2006) and other mechanisms that increase evolvability (Baquero, 2009).”
• Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review. (2013, background): “The biological treatment process creates an environment potentially suitable for resistance development and spread because bacteria are continuously mixed with antibiotics at sub-inhibitory concentrations (Auerbach et al., 2007; Davies et al., 2006; Ferreira da Silva et al., 2006).”
• Probiotics and competitive exclusion of pathogens in shrimp aquaculture (2020, background): “Investigation into the functional role of sub-inhibitory concentrations of antimicrobials has revealed their multifaceted nature (Fajardo & Mart ınez, 2008), with involvements in signalling (Davies et al., 2006; Linares et al., 2007; Romero et al., 2011), inhibition of quorum sensing (Hong et al.”
• Call of the wild: antibiotic resistance genes in natural environments (2010, background): “Almost all of the tested compounds exhibit hormesis”
• Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment (2017, neutral): “Specifically [41], showed that even at sub-inhibitory concentrations, antibiotics may still exert their biological impact on natural microbial communities by influencing transcription in microbes.”
• Antibiotics induce redox-related physiological alterations as part of their lethality (2014, background): “In nature, bacteria are most likely to be exposed to sublethal concentrations of antibiotics (103, 104), which have been shown to induce beneficial antibiotic mutagenesis capably (79).”
• Microbial Extracellular Polymeric Substances (EPSs) in Ocean Systems (2017, background): “Contrastingly, molecules that may act as signals for some bacteria, may act as antibiotics against other bacteria (Kaufmann et al., 2005; Davies et al., 2006; Schertzer et al., 2009; Johnson et al., 2016).”
• Horizontal Gene Exchange in Environmental Microbiota (2011, background): “SUB-INHIBITORY ANTIMICROBIALS During the recent years the concept of antibiotics as solely killing agents has been substantially revised in the light of new findings suggesting that low concentrations of antibiotics may play a regulatory function in natural ecosystems (Davies et al., 2006; Fajardo a”
• The rhizosphere microbiome: significance of plant beneficial, plant pathogenic, and human pathogenic microorganisms. (2013, background): “Recent studies have indeed shown that antibiotics function in a concentration-dependent manner, acting as growth inhibitors at high concentrations and as mediators of intercellular signaling at low concentrations (Davies et al., 2006; Fajardo & Martinez, 2008; Romero et al., 2011).”