Antibiotics induce redox-related physiological alterations as part of their lethality

By Daniel J. Dwyer, Peter Belenky, Jason H. Yang, I. C. MacDonald, Jeffrey D. Martell, N. Takahashi, Clement T. Y. Chan, M. Lobritz, D. Braff, Eric G. Schwarz and 9 more. Proceedings of the National Academy of Sciences of the United States of America, 2014

907 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/0d8a941d3c48ed2e112d59a9aaecd99b4f51813e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. James J. Collins
2. Ahmad S. Khalil
3. Daniel J. Dwyer
4. Dongbin Xiu

In Molecular Biology

1. James J. Collins
2. Ahmad S. Khalil
3. Daniel J. Dwyer
4. Yaakov Benenson
5. Dongbin Xiu
6. Christopher A. Voigt

In Molecular Medicine

1. James J. Collins
2. A. Singer

Citations in the corpus

• Antibiotic efficacy is linked to bacterial cellular respiration (2015, methodology): “With regard to cellular metabolic state, the efficacy of bactericidal antibiotic therapy has been linked to carbon flux through the TCA cycle (32, 33), and environmental factors that engage with central metabolism, such as the availability of molecular oxygen to feed the electron transport chain, ha”
• A white-box machine learning approach for revealing antibiotic mechanisms of action (2019, neutral): “, 2015), the biological mechanisms underlying antibioticinduced changes to metabolism (Belenky et al., 2015; Dwyer et al., 2014) remain unclear.”
• Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators (2016, background): “Hence, the mere presence of these radial oxygen species-inducing chemicals in the environment ensures that spontaneous mutations will occur at a greater rate and that antibiotic resistance can form de novo (Isidori et al., 2005; Kohanski et al., 2010; Dwyer et al., 2014).”