Platelets in atherothrombosis

By Zaverio M. Ruggeri. Nature Medicine, 2002

1,726 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Hematology

View Paper: https://www.semanticscholar.org/paper/1ad653c6149e5b6f2a77cb2c1499bfa479460f21

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. S. Shattil
2. M. Levi
3. P. Newman
4. S. Jackson

In Hematology

1. S. Shattil
2. H. Versteeg
3. Pieter H. Reitsma
4. J. Heemskerk
5. M. Levi
6. P. Newman
7. S. Jackson

Citations in the corpus

• Kindlin-3 is essential for integrin activation and platelet aggregation (2008, background): “dtd" [ ]> Integrin-mediated platelet adhesion and aggregation are essential for sealing injured blood vessels and preventing blood loss, and excessive platelet aggregation can initiate arterial thrombosis, causing heart attacks and strok”
• Integrins: dynamic scaffolds for adhesion and signaling in platelets. (2004, background): “112,117 (3) Src and/or Syk phosphorylate”
• A shear gradient–dependent platelet aggregation mechanism drives thrombus formation (2009, background): “1955" language="eng" relation="no"> Platelet aggregation at sites of vascular injury is central to the arrest of bleeding and for subsequent vascular repair; however, an exaggerated platelet aggregation response at sites of atherosclerotic plaque rupture can lead to the development of vascu”
• Update on acute coronary syndromes: the pathologists' view. (2013, background): “are more important and promote thrombosis via shear-induced platelet activation.(133) A platelet-rich thrombus may indeed form”
• Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo (2009, neutral): “Platelets play a pivotal role in vascular occlusive disease (Furie and Furie, 2008; Ruggeri, 2002).”
• Defective thrombus formation in mice lacking coagulation factor XII (2005, background): “Platelets are initially tethered to the ECM by von Willebrand factor through platelet glycoprotein Ib ( 46 ).”
• SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. (2008, background): “This may be due to the fact that, in resting platelets, integrins are inactive and signaling into the cell is only induced upon stimulation via molecules like thrombin or collagen (Ruggeri, 2002).”
• Arterial thrombosis—insidious, unpredictable and deadly (2011, background): “However, it is becoming increasingly clear that the cellular and biochemical interactions underlying thrombosis are also directly relevant to atherosclerosi”
• New fundamentals in hemostasis. (2013, background): “Pathological thrombus formation, which we will not discuss in detail, additionally involves other factors like high shear stress and dysfunctions of endothelial cells (255).”