A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

By W. Nesbitt, E. Westein, F. Tovar-Lopez, E. Tolouei, Arnan Mitchell, Jiahong Fu, J. Carberry, A. Fouras, S. Jackson. Nature Medicine, 2009

875 citations recorded by the source corpus.

How researchers see this paper

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Platelets in Inflammation and Atherogenesis (2015, background): “Arterioscler Thromb Vasc Biol (2005) 25(10):2054–61.”
Platelet secretion: From haemostasis to wound healing and beyond (2015, background): “Despite many different agonists shown to drive platelet activation in vitro to completion, it is now known that in vivo platelet activation is non-homogeneous, possibly attributable to variations in shear under physiological conditions [16,17].”
New fundamentals in hemostasis. (2013, background): “Recent studies point to a gradient in platelet activation, with discoid, loosely aggregated platelets at the surface of a thrombus (197), and a gradually increased activation level deeper in the thrombus where tight platelet-platelet contacts are formed (11, 36).”
Arterial thrombosis—insidious, unpredictable and deadly (2011, background): “Thus, propagation of a thrombus into the lumen of an injured artery prompts blood flow to accelerate at the surface of the growing thrombu”