Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA

By D. Kelly, J. Campbell, T. King, G. Grant, Emmelie A Jansson, A. Coutts, S. Pettersson, S. Conway. Nature Immunology, 2004

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Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, neutral): “lowered the transcription of NF-κB-dependent genes [126].”
The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation (2009, background): “Although several studies have shown that culture supernatants from probiotic strains attenuate pathogen infection (6, 7), modulate inflammation in dendritic cells (8) and Caco-2 cells (9), and increase intestinal epithelial cell barrier function (10), the specific molecules contributing to these res”
The Balance of Th17 versus Treg Cells in Autoimmunity (2018, background): “Likewise, Bacteriodes thetaiotamicron plays an anti-inflammatory role by controlling PPAR-γ trafficking between the nucleus and cytoplasm [91].”
The challenges of modeling mammalian biocomplexity (2004, background): “and can influence the immune status as well as such factors as peroxisome proliferator activated receptor γ nuclear cytoplasmic shuttling in the host, once thought to be purely under mammalian genome contro”
Gut microorganisms, mammalian metabolism and personalized health care (2005, background): “thetaiotaomicron has also been shown to influence the transport and regulation of mammalian peroxisome proliferator-activated receptor-γ (PPARγ), an intranuclear receptor that is highly expressed in host adipose tissue by an unknown mechanis”