The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

By T. Bansal, R. Alaniz, Thomas K. Wood, A. Jayaraman. Proceedings of the National Academy of Sciences of the United States of America, 2009

795 citations recorded by the source corpus.

Subfields: Endocrinology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/5bb995112bd3150703880c7bfdeaf7dd8e3c69c2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. Lan Lin
2. Jianqiong Zhang
3. Eran Elinav

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. Patrice D Cani
5. F. Bäckhed
6. P. Kennedy
7. S. Mazmanian
8. N. Delzenne

In Neurology

1. Patrice D Cani

Citations in the corpus

• Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism (2018, background): “PXR-deficient mice exhibit a leaky gut and reduced expression of Muc2 in the small intestine (Venkatesh et al., 2014).”
• Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity (2014, background): “In in vitro studies, indolic compounds were shown to improve intestinal cell barrier function and to decrease proinflammatory IL-8 expression (66, 67).”
• Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified (2013, background): “[76] hypothesized that indole is an inter kingdom signal in intestinal epithelial cells and play a strengthening effect on host cell-barrier properties.”
• Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4 (2014, positive): “In humans under homeostatic conditions, blood IPA and indole concentrations remain in micromolar and millimolar range, respectively, with intestinal concentrations predicted to be much higher (Bansal et al., 2010).”
• Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, result): “Analogous to the observations with probiotics strains, this study strongly suggested that commensal-secreted indole could serve as a beneficial signaling molecule for intestinal epithelial cells and thus be crucial in the protective responses to gut pathogens [130].”
• Animals in a bacterial world, a new imperative for the life sciences (2013, background): “Proc Natl Acad Sci USA 107(18):8375–8380.”
• Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages (2018, positive): “In a previous study (Bansal et al., 2010), we found that the tryptophan-derived bacterial metabolite indole attenuates indicators of inflammation in epithelial cells.”
• Interaction between microbiota and immunity in health and disease (2020, background): “, via the metabolite indole, promote fortification of the epithelial barrier through upregulation of tight junctions and associated cytoskeletal proteins.(45) In addition, secretory IgA antibodies and antimicrobial peptides (AMPs) maintain the mucosal barrier function (see below).”
• Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “Indoles produced by bacteria also have a beneficial impact on intestinal epithelial cells by acting to strengthen the mucosal barrier (Bansal et al., 2010).”