PPARs at the crossroads of lipid signaling and inflammation.

By W. Wahli, L. Michalik. Trends in endocrinology and metabolism, 2012

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Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy and mitochondrial fusion dynamics (2015, background): “In addition, because FAs and their derivatives play important roles in regulating cellular signaling cascades and contribute to FAdriven modulations in metabolism, inflammatory responses, and cell death programs (Calder, 2013; Wahli and Michalik, 2012; Zechner et al., 2012), alterations in their lev”
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. (2014, background): “…p62 and PPARg Limit Inflammation during ''Metabolic Activation'' The induction of PPARg in proinflammatory MMe macrophages seemed surprising given that saturated FFAs are poor PPARg ligands (Wahli and Michalik, 2012) and that PPARg exerts antiinflammatory effects (Odegaard et al., 2007).”
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease (2015, positive): “A contributing factor to the increased sensitivity of Nrf2−/− mice to inflammation may be loss of peroxisome proliferator-activated receptor γ (Pparγ) because it is known that Nrf2 positively regulates Pparγ [185] and that Pparγ exerts strong anti-inflammatory effects [186].”