Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.
By Toshiro Sato, D. Stange, M. Ferrante, R. Vries, J. van Es, Stieneke van den Brink, W. V. van Houdt, A. Pronk, J. V. van Gorp, Peter D. Siersema and 1 more. Gastroenterology, 2011
3,443 citations recorded by the source corpus.
Subfields: Biotechnology, Hepatology, Oncology
View Paper: https://www.semanticscholar.org/paper/19dc828411011d5127715f35a58507048e708ac1
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biotechnology
In Hepatology
In Oncology
Citations in the corpus
- An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, background): “Wnt signaling can be further augmented by secreted R-spondin proteins (9, 10).”
- Modeling Development and Disease with Organoids. (2016, background): “Cancer Once culturing protocols for human aSC-based organoids were established, we have shown the feasibility of growing organoids from primary colon, prostate, and pancreatic cancers (Boj et al., 2015; Gao et al., 2014; Sato et al., 2011; van de Wetering et al., 2015).”
- A Landscape of Pharmacogenomic Interactions in Cancer (2016, background): “New cell culturing technologies enable derivation of patient cell lines with high efficiency and thus make derivation of a larger set of cell lines encompassing the molecular diversity of cancer a realistic possibility (Liu et al., 2012; Sato et al., 2011).”
- Prospective derivation of a Living Organoid Biobank of colorectal cancer patients (2015, methodology): “We adapted the culture condition for long-term expansion of human colonic epithelium and primary colonic adenocarcinoma, by adding nicotinamide, A83-01 (Alk inhibitor), Prostaglandin E2, and the p38 inhibitor SB202190 (Sato et al., 2011).”
- SARS-CoV-2 productively infects human gut enterocytes (2020, methodology): “hSIOs are established from primary gut epithelial stem cells, can be expanded indefinitely in 3D culture and contain all proliferative and differentiated cell types of the in vivo epithelium (23).”
- Human Primary Liver Cancer -derived Organoid Cultures for disease modelling and drug screening (2017, neutral): “Accordingly, 77 mouse and human cancer organoids have recently been established for colon [16-18], 78”
- Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease (2018, methodology): “To test this, we used a ‘‘mini-gut’’ culture system (Sato et al., 2011) that allows the growth of human colonic crypts into organoids.”