Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin.

By M. Meneghini, M. Wu, H. Madhani. Cell, 2003

714 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/19a4cbc1d44da4e33f715bdfc21119350b1f1cf6

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In Molecular Biology

Citations in the corpus

H2A.Z-containing nucleosomes mediate the thermosensory response in Arabidopsis. (2010, neutral): “The Htz1 transcriptome has been previously determined (Meneghini et al., 2003), and we therefore tested to see if those genes that are misregulated in the htz1D background also show a corresponding change when wild-type yeast are shifted from 29 C to 33 C (Gasch et al., 2000).”
High-resolution profiling of histone methylations in the human genome. (2007, background): “In yeast, it is bound to regions near telomeres and large numbers of both active and silent yeast promoters and has been suggested to act as an antisilencing factor (Meneghini et al., 2003), reviewed by (Guillemette and Gaudreau, 2006).”
Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. (2005, methodology): “Z (Meneghini et al., 2003) and three histone modifications: acetylation on lysine 16 of the H4 tail (Kimura et al., 2002; Suka et al., 2002) and methylation of lysines 4 and 79 of H3 (Ng et al., 2003a; Santos-Rosa et al., 2004; van Leeuwen et al., 2002).”
A Protein Complex Containing the Conserved Swi2/Snf2-Related ATPase Swr1p Deposits Histone Variant H2A.Z into Euchromatin (2004, methodology): “Z, the Sir complex spreads beyond its normal boundaries at HMR and into neighboring euchromatin, resulting in the repression of gene expression (Meneghini et al. 2003).”
Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss. (2005, neutral): “Furthermore, we find that telomere-proximal IGRs (within 20 kb of the telomere) show average occupancy (mMPR 50%), an unexpected result considering the strong downregulation of genes near telomeres in htz1 cells ( Meneghini et al., 2003; see Discussion).”