New insights into the classification and nomenclature of cortical GABAergic interneurons

By J. DeFelipe, Pedro L. López-Cruz, Ruth Benavides-Piccione, Concha Bielza, Pedro Larrañaga, S. Anderson, A. Burkhalter, B. Cauli, A. Fairén, D. Feldmeyer and 32 more. Nature Reviews Neuroscience, 2013

814 citations recorded by the source corpus.

A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus.

Subfields: Biophysics, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/188cbc85794eb87fe331adb8c306d2c61ab547c0

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In Biophysics

Henning Sprekeler

In Cognitive Neuroscience

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Citations in the corpus

Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function (2014, background): “Twenty-one different classes of interneurons have been distinguished in the CA1 region of the hippocampus (5), and it is likely that an even larger number of types can be dissected in the neocortex (6).”
Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain (2015, background): “eminence (MGE), the birthplace of cortical PV neurons (DeFelipe et al., 2013).”
Inhibitory circuits of the mammalian main olfactory bulb. (2017, background): “Results from this study demonstrated that, similar to neocortical interneurons (DeFelipe et al. 2013), dSACs can be divided into largely nonoverlapping subclasses based on their axonal projections, yielding GCL-, EPL-, and GL-projecting dSACs (GCL-, EPL-, and GL-dSACs, respectively) (Eyre et al.…”
Adult Mouse Cortical Cell Taxonomy by Single Cell Transcriptomics (2016, neutral): “…for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms based on quantitative features has been challenging, and our understanding of the extent of cell type diversity remains incomplete 4, 9, 10 .”
Receptive field formation by interacting excitatory and inhibitory synaptic plasticity (2016, background): “In part, this is likely due to the diversity of inhibitory cell types (Markram et al., 2004; Klausberger & Somogyi, 2008; DeFelipe et al., 2013) and their largely unresolved functional roles.”
Inhibition of Inhibition in Visual Cortex: The Logic of Connections Between Molecularly Distinct Interneurons (2013, neutral): “The lack of a clear relationship between morphological and molecular characteristics[4,5,19], precludes a general overview of the connectivity between cortical interneurons.”
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015, background): “Foundational aspects of each point have not been agreed: the definition of a cell type in the brain remains controversial 20,21 ; the relationships of human disease phenotypes to developmental trajectories are relatively unknown; model systems in many neurobiological studies are often chosen on the…”
Principles of connectivity among morphologically defined cell types in adult neocortex (2015, neutral): “of neuron from another is a matter of considerable interest and debate (2, 4).”
Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments (2019, background): “The 5-HT3a receptor subtype is further defined by expression of vasoactive intestinal peptide (VIP) and can be bipolar or multipolar (DeFelipe et al., 2013).”