Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering.

By A. V. Wright, James K. Nuñez, Jennifer A. Doudna. Cell, 2016

965 citations recorded by the source corpus.

Subfields: Business and International Management, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/d54327dc2146a8c34c8df5f3615da5c9e27187bb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Business and International Management

1. Feng Zhang
2. Eugene V. Koonin
3. Kira S. Makarova

In Molecular Biology

1. Feng Zhang
2. Eugene V. Koonin
3. Kira S. Makarova
4. Bernd Zetsche
5. Jerilyn A. Timlin
6. J. Carney
7. J. C. Harper
8. Christopher A. Lino

In Plant Science

1. Feng Zhang
2. Jerilyn A. Timlin
3. Eugene V. Koonin
4. J. Carney
5. J. C. Harper
6. Christopher A. Lino

Citations in the corpus

• Crystal structure of Cpf1 in complex with guide RNA and target DNA (2016, background): “The microbial adaptive immune system CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPRassociated proteins) helps bacteria and archaea defend themselves against the invasion of foreign nucleic acids (Marraffini, 2015;Wright et al., 2016).”
• C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector (2016, neutral): “, insertion of foreign nucleic acid segments (spacers) into the CRISPR array in between pairs of direct repeats (DRs), (ii) transcription and processing of the CRISPR array to produce mature CRISPR RNAs (crRNAs), and (iii) interference, whereby Cas enzymes are guided by the crRNAs to target and clea”
• Delivering CRISPR: a review of the challenges and approaches (2018, background): “CRISPR systems were further classified into six types that were additionally grouped into two classes (Wiedenheft et al., 2011; Wright et al., 2016).”
• CRISPR-Cas12a: Functional overview and applications (2020, background): “1), each step needs specific Cas proteins encoded by the cas genes near the CRISPR array, together with other accessory proteins [2,28,29].”
• Transcriptional Addiction in Cancer (2017, neutral): “The recent development of genetic and epigenetic editing technologies that can manipulate or repair chromosomal neighborhoods suggests novel therapeutic strategies for such modified cancer genomes (Amabile et al., 2016; Doudna and Charpentier, 2014; Liu et al., 2016b; Wright et al., 2016).”