Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis.

By S. Funamoto, Ruedi Meili, Susan Lee, L. Parry, R. Firtel. Cell, 2002

808 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/17f6f4a1ab5951247e2537453e03ed13fd2ebc73

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. M. Raftopoulou
2. A. Hall
3. P. Pandolfi
4. P. Kubes
5. Arkaitz Carracedo
6. C. Der

In Immunology and Allergy

1. C. Gerard
2. P. Kubes
3. M. Phillipson

In Molecular Biology

1. Arkaitz Carracedo
2. M. Raftopoulou
3. P. Pandolfi
4. Y. Bae
5. A. Hall
6. C. Serhan
7. S. Rhee
8. P. Kubes

Citations in the corpus

• Directional Sensing Requires G-Mediated PAK1 and PIX-Dependent Activation of Cdc42 (2003, background): “This conclusion is consis- PIX was also implicated as a candidate gene for tent with what was observed in chemotactic Dictyoste- X linked mental retardation based on disruption, by lium cells (Funamoto et al., 2002; Iijima and Devreotes, chromosome rearrangement, of the PIX gene of a sin2002).”
• Mechanism of B-Cell Receptor-Induced Phosphorylation and Activation of Phospholipase C-γ2 (2004, background): “Alternatively, because intracellular concentration of PIP3 is the net result of phosphorylation by PI 3-kinase and dephosphorylation by PTEN and because PIP3 is not evenly distributed throughout the plasma membranes (14, 15, 18, 51), Akt and Btk might be activated by different pools of PIP3, and the”
• International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family (2009, background): “The “backness” or uropod of a migrating cell is characterized by concentrations of molecules such as PTEN, RhoA, and the G12/13 family of G proteins (Funamoto et al., 2002; Xu et al., 2003).”
• Chemotaxis: signalling the way forward (2004, background): “This provides a robust mechanism to generate PtdIns(3,4,5)P 3 locally at the leading edg”
• Dynamic Partitioning into Lipid Rafts Controls the Endo-Exocytic Cycle of the αL/β2 Integrin, LFA-1, during Leukocyte Chemotaxis (2005, background): “By being recruited to the posterior edge of migrating cells, PTEN contributes to establishing an internal anterior-posterior gradient of the phosphatidylinositol 3,4,5-phosphate lipid messenger, which is required to impart directionality to the moving cell (Funamoto et al., 2002; Iijima and Devreote”
• Cell migration: Rho GTPases lead the way. (2004, background): “Elegant studies in Dicytostelium have shown that the localization of PI 3-kinase at the front is coupled to a restricted distribution of its antagonist, the PI(3,4,5)P3 phosphatase PTEN, at the rear, and that this is essential for chemotaxis (Funamoto et al., 2002; Iijima and Devreotes, 2002).”
• The neutrophil in vascular inflammation (2011, background): “It is worth mentioning that there is a body of work that suggests that SHIP rather than PTEN is the important phosphatase in this process 29 .”
• The PTEN–PI3K pathway: of feedbacks and cross-talks (2008, background): “Studies carried out in Dictyostelium and hippocampal neurons show that the proper cross-talk of these two pathways is essential for axon formation and cell polarity and migration (Funamoto et al., 2002; Sasaki et al., 2004, 2007; Fivaz et al., 2008).”