CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

By J. Irie-Sasaki, Takehiko Sasaki, W. Matsumoto, A. Opavsky, M. Cheng, G. Welstead, E. Griffiths, C. Krawczyk, C. Richardson, K. Aitken and 6 more. Nature, 2001

597 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/17ea449bc67190a0b12b4043701153be00e14422

How researchers see this paper

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In Immunology

1. Rhiannon Morris
2. Bin Liu
3. J. Babon
4. N. Kershaw
5. K. Shuai

In Oncology

1. Rhiannon Morris
2. Bin Liu
3. J. Babon
4. N. Kershaw
5. K. Shuai

Citations in the corpus

• Regulation of JAK–STAT signalling in the immune system (2003, background): “CD45 can directly bind and dephosphorylate all JAK”
• The molecular details of cytokine signaling via the JAK/STAT pathway (2018, background): “CD45 is highly expressed in hematopoietic cells and thought to dephosphorylate all four JAK proteins.(13,212) Cells deficient in CD45 display extended signaling in response to IL-7, EPO, and interferon stimulation.”
• Biological Insights into TCRγδ+ and TCRαβ+ Intraepithelial Lymphocytes Provided by Serial Analysis of Gene Expression (SAGE) (2001, unknown): “In sum, these that interference with cytokine receptor signaling is achieved by CD45 via dephosphorylation of jak kinasesstaining profiles provided a further, general distinction of IELs from both resting and activated splenic CD8 T (Irie-Sasaki et al., 2001).”
• The JAK/STAT signaling pathway: from bench to clinic (2021, background): “The transmembrane PTP CD45 can inhibit IL-3-induced JAK2 phosphorylation and negatively regulate JAK/STAT signal transduction, thereby inhibiting IL-3-mediated cell proliferation.(177) PTP1B can act on specific sequences in the JAK activation loop in the cytoplasm, dephosphorylating JAK2 and TYK2, b”