Inflammation in neurodegenerative disease--a double-edged sword.

By T. Wyss‐Coray, L. Mucke. Neuron, 2002

1,231 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/17a8ba0d1ea08ef29749e06e190e257793bfa0c4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. S. Lehnardt
2. M. Hanani
3. T. Wyss‐Coray
4. Beth Stevens
5. A. Stephan
6. B. Barres

In Neurology

1. B. Barres
2. Beth Stevens
3. S. Lehnardt
4. M. Hanani
5. T. Wyss‐Coray
6. L. Zuo
7. J. Rogers
8. Zewen Liu

In Physiology

1. J. Rogers
2. M. Goldberg
3. M. Tansey
4. B. Barres
5. S. Lehnardt
6. M. Hanani
7. T. Wyss‐Coray
8. L. Zuo

Citations in the corpus

• Satellite glial cells in sensory ganglia: from form to function. (2005, background): “substances that may have beneficial or detrimental influence depending on the circumstances [181,186].”
• Role of neuroinflammation in neurodegenerative diseases (Review) (2016, neutral): “…by producing factors that influence surrounding astrocytes and neurons (14), particularly in response to pathogen invasion or tissue damage thereby promoting an inflammatory response that further engages a self-limiting response through the immune system and initiates tissue repair (15).”
• Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity (2014, neutral): “The glial response can be considered as an innate immunemechanism, whereas the participation in the neuroinflammatory process of lymphocytes (mainly T cells) carrying binding sites for specific antigens is an acquired immunemechanism [14].”
• Neuroinflammation in Parkinson’s disease: its role in neuronal death and implications for therapeutic intervention (2009, background): “…often represents a beneficial event (WyssCoray, 2006), long-term global inhibition of pro-inflammatory responses may not be the most effective strategy to treat the inflammatory condition associated with neurodegenerative diseases (Wyss-Coray and Mucke, 2002; Marchetti and Abbracchio, 2005).”
• Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain (2007, background): “However, whether microglial activation has beneficial or detrimental effects on adjacent ischemic neurons remains controversial (Nguyen et al., 2002; Wyss-Coray and Mucke, 2002; Nedergaard and Dirnagl, 2005).”
• Molecular Inflammation: Underpinnings of Aging and Age-related Diseases (2008, background): “Much research suggests that the immune response to Aβ can exacerbate ongoing pathological processes, but the role that inflammation plays in the disease process is complex (Wyss-Coray and Mucke, 2002).”
• Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury (2009, background): “incessant process to guarantee the organ’s integrity, its injurious property also has to be taken into account (Wyss-Coray and Mucke, 2002).”
• Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. (2012, background): “The consequences of cytokine or chemokine changes on brain function and neurodegeneration relevant to AD are unknown, but a growing number of genetic studies in mice show that these immune proteins have potent effects on amyloidosis, neurodegeneration, and cognition (Wyss-Coray and Mucke 2002; Wyss-”
• ER stress and neurodegenerative diseases (2006, background): “of many neurodegenerative disorders and contributes to the overall disease process.(15) Apart from the classical caspasedependent cell death, other types of death mechanisms have also been described in various cell types including neurons that may or may not involve the mitochondria.”