Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

By J. Scher, A. Sczesnak, R. Longman, Nicola Segata, C. Ubeda, C. Bielski, T. Rostron, V. Cerundolo, Eric G. Pamer, S. Abramson and 2 more. eLife, 2013

1,842 citations recorded by the source corpus.

Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a role for intestinal bacteria in supporting the systemic immune response required for joint inflammation. Here we performed 16S sequencing on 114 stool samples from rheumatoid arthritis patients and controls, and shotgun sequencing on a subset of 44 such samples. We identified the presence of Prevotella copri as strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) patients. Increases in Prevotella abundance correlated with a reduction in Bacteroides and a loss of reportedly beneficial microbes in NORA subjects. We also identified unique Prevotella genes that correlated with disease. Further, colonization of mice revealed the ability of P. copri to dominate the intestinal microbiota and resulted in an increased sensitivity to chemically induced colitis. This work identifies a potential role for P. copri in the pathogenesis of RA. DOI: http://dx.doi.org/10.7554/eLife.01202.001

Subfields: Epidemiology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b925428d83156693ebf7cfb4e3cc67d5462e44d0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Infectious Diseases

In Molecular Biology

Citations in the corpus

Microbial strain-level population structure and genetic diversity from metagenomes (2017, positive): “(Koren et al. 2013) and has been strongly associated with the onset of rheumatoid arthritis (Scher et al. 2013; Zhang et al. 2015).”
LinDA: linear models for differential abundance analysis of microbiome compositional data (2021, neutral): “The CDI, IBD, RA, SMOKE and COMBO datasets are from [29, 30, 31, 32, 45], respectively.”
Gut microbiota dysbiosis contributes to the development of hypertension (2017, background): “Researchers previously suggested that the intestinal bacterium Prevotella copri thrives in a pro-inflammatory environment of rheumatoid arthritis [3, 49].”
Immunopathogenesis of rheumatoid arthritis (2017, positive): “Bacteroides species were decreased in the same patients (Scher et al., 2013).”
Decreased Bacterial Diversity Characterizes an Altered Gut Microbiota in Psoriatic Arthritis and Resembles Dysbiosis of Inflammatory Bowel Disease (2015, methodology): “The authors wish to thank Drs. Pamela Rosenthal, Peter Izmirly, Jonathan Samuels, Jerome Shupak, Gary Zagon, and Gary Solomon (NYU School of Medicine) for patient recruitment and performance of clinical assessments, Agnes Viale and Lauren Lipuma (Memorial Sloan-Kettering Cancer Center) and Núria Bo”
Diagnosis and Management of Rheumatoid Arthritis: A Review (2018, positive): “Environmental risk factors for RA are smoking, periodontitis, and characteristics of the microbiome of the gut, mouth, and lungs, as well as viral infections.(13,18) Regarding the microbiome, Prevotella species, which are expanded in the gastrointestinal tract in early RA, and Porphyromonas gingival”
The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “Patients with RA show expansion of enteric Prevotella copri (Scher et al., 2013), and autoantigens in these patients exhibit high homology to Prevotella-associated peptides (Pianta et al., 2017).”
Interaction between the gut microbiome and mucosal immune system (2017, background): “Bacteroides were found in early RA patients [91], indicating the influence of Prevotellain RA disease develop-”
Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine (2016, background): “lation (15), Prevotella species, particularly P copri, was”