Molecular physiology of P2X receptors.

By R. North. Physiological Reviews, 2002

3,004 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Physiology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/176cfe9afceb31dd6e768413e9ead95b5d34489b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. G. Burnstock
2. F. Di Virgilio
3. A. Sarti
4. S. Falzoni
5. A. Giuliani
6. D. Dal Ben
7. P. Pelegrín
8. Andrea Volterra

In Physiology

1. G. Burnstock
2. F. Di Virgilio
3. A. Sarti
4. S. Falzoni
5. A. Giuliani
6. D. Dal Ben
7. Maria P. Abbracchio
8. P. Pelegrín

In Social Psychology

1. P. Pelegrín
2. Andrea Volterra
3. A. Giuliani
4. A. Sarti
5. A. Surprenant
6. S. Falzoni
7. G. Knight
8. G. Burnstock

Citations in the corpus

• Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins. (2006, background): “Precrystallization Screening of P2X Receptors P2X receptors are eukaryotic integral membrane proteins that form ion channels gated by ATP (Khakh, 2001; North, 2002).”
• Astrocytes, from brain glue to communication elements: the revolution continues (2005, background): “However, its pharmacology is different: it is activated by ATP at high concentrations (EC 50 = 300 μM), by 3′-O-(4-benzoylbenzoyl) ATP (BzATP) at lower concentrations, and can be blocked by oxidized ATP but not by surami”
• The P2X7 Receptor in Infection and Inflammation (2017, positive): “P2RX7 encodes a 595-aa protein (the P2X7 subunit or monomer) that assembles into a trimeric complex to form the functional P2X7R (Surprenant et al., 1996; North, 2002).”
• Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor (2006, background): “All protocols and extracellular solutions were the same under both systems: YoPro1 (2mM) or ethidium bromide (20mM) was present throughout unless otherwise stated; because YoPro1 and GFP fluorescence overlap, ethidium (red spectrum) was used in all experiments involving transient transfections as we”
• International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy (2006, background): “After cloning of P2 receptors and studies of transduction mechanisms in the early 1990s, the basis for subdivision into P2X and P2Y receptor families was confirmed and extended (Abbracchio and Burnstock, 1994) and seven subtypes of P2X receptors and eight subtypes of P2Y receptors are currently reco”
• Physiology of Astroglia. (2018, neutral): “The P2X7 receptors are unique in their low ATP sensitivity (in all probability it is ATP that acts as a true agonist), almost complete absence of desensitization, and ability to produce large transmembrane pores upon intense stimulation (1239).”