Reprogramming of human somatic cells to pluripotency with defined factors

By In-Hyun Park, Ruili Zhao, Jason A West, A. Yabuuchi, Hongguang Huo, Tan A. Ince, Paul Lerou, M. Lensch, G. Q. Daley. 2008

2,968 citations recorded by the source corpus.

Subfields: Molecular Biology

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In Molecular Biology

1. S. Yamanaka
2. K. Hochedlinger
3. M. Stadtfeld
4. R. Jaenisch
5. G. Keller
6. Kathrin Plath
7. G. Daley
8. Marius Wernig

Citations in the corpus

• Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency (2010, background): “Initially, we attributed the lower and variable differentiation of iPSCs to transgene expression, because iPSCs generated using lentiviruses or retroviruses showed residual transgene expression (10, 11) that we believed inhibited the iPSCs from efficiently differentiating.”
• Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009, background): “As reported previously with either lentiviral or Moloney-based retroviral vectors (Dimos et al., 2008; Ebert et al., 2009; Hockemeyer et al., 2008; Park et al., 2008a; Yu et al., 2007), we detected residual expression of the reprogramming factors for most of the transgenes in all cell lines with…”
• EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay (2017, methodology): “…cMYC, ABCG2, DNMT3B, and GDF3 genes was quantified by real-time PCR with Power SYBR Green PCR master mix (Applied Biosystems) on a Real Time PCR analyzer (7500; Applied Biosystems) and normalized to the human β-actin (hACTB) gene expression using primers previously reported (Park et al., 2008).”
• An extended transcriptional network for pluripotency of embryonic stem cells. (2008, background): “The recognition that human skin cells can be reprogrammed to iPS cells with the same factors that are active in mouse cells (Park et al., 2007; Takahashi et al., 2007; Yu et al., 2007) provides strong evidence in favor of common networks in pluripotent mouse and human cells, despite differences in…”
• Nuclear reprogramming to a pluripotent state by three approaches (2010, background): “Human iPS cells were obtained within a year by inducing overexpression of the same combination of factor”
• Disease-specific induced pluripotent stem (iPS) cells (2008, positive): “Following 2 to 3 weeks of culture in hES cell-supporting conditions, compact refractile ES-like colonies emerged among a background of fibroblasts, as previously described (Park et al., 2008a, 2008b).”