Alzheimer’s Disease: The Challenge of the Second Century

By D. Holtzman, John C. Morris, A. Goate. Science Translational Medicine, 2011

1,386 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/16c546a8d31c35eb2604a591d9825aaddf80fd82

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. D. Holtzman
2. M. Colonna
3. Peng Yuan
4. Lary C. Walker
5. T. Miller
6. Li-Huei Tsai
7. Mathias Jucker
8. William W. Seeley

In Physiology

1. D. Holtzman
2. Mathias Jucker
3. Lary C. Walker
4. M. Colonna
5. Li-Huei Tsai
6. Louise C. Serpell
7. William W. Seeley
8. F. Collin

In Psychiatry and Mental health

1. Peng Yuan
2. Lary C. Walker
3. Mathias Jucker
4. William W. Seeley
5. D. Holtzman
6. J. Grutzendler
7. J. Long

Citations in the corpus

• Oxidative stress and the amyloid beta peptide in Alzheimer’s disease (2017, background): “The mutations in the mid-domain of Aβ region in APP alters Aβ assembly by increasing the propensity of Aβ to form oligomers and fibrils [30].”
• Pathogenic Protein Seeding in Alzheimer’s Disease and Other Neurodegenerative Disorders (2011, background): “Early intervention will require an early and informative biomarker.(4,95) In vitro, the formation of corruptive seeds is a relatively slow, stochastic process,(96) although once a seed is present, aggregation proceeds quite rapidly.”
• TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques (2016, background): “Key pathological features of AD consist of the deposition of amyloid-β peptide (Aβ) and hyperphosphorylated tau aggregates that, together, are linked with synapse loss and neuronal cell death, as well as activation of microglia and astrocytes (Holtzman et al., 2011).”
• Early remodeling of the neocortex upon episodic memory encoding (2014, background): “For instance, the mPFC is among the first brain regions to develop amyloid-β (Aβ) plaque deposition, an early pathological hallmark of AD (50).”
• Alzheimer's disease risk genes and mechanisms of disease pathogenesis (2014, neutral): “Neuroinflammation and dysregulation of the immune response is a central feature of AD (2).”
• Distinct tau prion strains propagate in cells and mice and define different tauopathies (2014, background): “Alzheimer’s disease (AD), the most common tauopathy, affects >30 million people worldwide and will afflict >120 million by 2050 (Holtzman et al., 2011).”