Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
By Clémence Cheignon, M. Tomás, D. Bonnefont-Rousselot, P. Faller, C. Hureau, F. Collin. Redox Biology, 2017
1,868 citations recorded by the source corpus.
Oxidative stress is known to play an important role in the pathogenesis of a number of diseases. In particular, it is linked to the etiology of Alzheimer’s disease (AD), an age-related neurodegenerative disease and the most common cause of dementia in the elderly. Histopathological hallmarks of AD are intracellular neurofibrillary tangles and extracellular formation of senile plaques composed of the amyloid-beta peptide (Aβ) in aggregated form along with metal-ions such as copper, iron or zinc. Redox active metal ions, as for example copper, can catalyze the production of Reactive Oxygen Species (ROS) when bound to the amyloid-β (Aβ). The ROS thus produced, in particular the hydroxyl radical which is the most reactive one, may contribute to oxidative damage on both the Aβ peptide itself and on surrounding molecule (proteins, lipids, …). This review highlights the existing link between oxidative stress and AD, and the consequences towards the Aβ peptide and surrounding molecules in terms of oxidative damage. In addition, the implication of metal ions in AD, their interaction with the Aβ peptide and redox properties leading to ROS production are discussed, along with both in vitro and in vivo oxidation of the Aβ peptide, at the molecular level.
Subfields: Computational Theory and Mathematics, Pharmacology, Physiology
View Paper: https://www.semanticscholar.org/paper/75756c2da2628f3e5b621723b826084b07d333ad
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Citations in the corpus
- Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases (2019, background): “The link between oxidative stress and the amyloid beta peptide has been recently reviewed [111].”
- Copper homeostasis and cuproptosis in health and disease (2022, background): “Excess Cu could bind directly to Aβ peptides with high affinity, further increasing aggregation of Aβ and driving increased neurotoxicity.(97,98) Binding of Cu to Aβ leads to the formation of neurotoxic dityrosine-linked β-amyloid dimers, which prevents the dimers from degrading to monomers and may ”
- An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases (2022, background): “Moreover, due to the lowering of estrogen levels during menopause and longer life expectancy, women are more likely to develop AD than men [42,43].”