NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus

By A. Tashiro, V. Sandler, N. Toni, Chunmei Zhao, Fred H. Gage. 2006

661 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Such enhanced plasticity may give adultborn neurons an advantage in the competition with mature neurons for selective formation and stabilization of afferent and efferent synaptic connections (Tashiro et al., 2006; Toni et al., 2007).”
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “Between 2 and 3 weeks of age, the survival of adult-born DGCs depends on NMDA-receptor mediated cell-autonomous activit”
Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling (2007, background): “There is emerging evidence that the maturation and integration of newborn neurons progress as distinct developmental steps that are at least partially regulated by activity-dependent mechanisms (Ming and Song, 2005; Overstreet Wadiche et al., 2005; Ge et al., 2006; Tashiro et al., 2006).”
Experience-Specific Functional Modification of the Dentate Gyrus through Adult Neurogenesis: A Critical Period during an Immature Stage (2007, background): “…regulation of responsiveness suggests changes in the connectivity of new neurons as a population, possibly mediated by the selective survival (Tashiro et al., 2006) and enhanced plasticity (Wang et al., 2000; SchmidtHieber et al., 2004; Zhao et al., 2006) of new neurons (supplemental text 2,…”
Computational influence of adult neurogenesis on memory encoding. (2009, positive): “The regulation of survival appears to be particularly dependent on activity, as new neurons pass through a critical period for survival that requires NMDA activation and that benefits strongly from environmental enrichment (Tashiro et al., 2006, 2007).”
The effects of exercise and stress on the survival and maturation of adult-generated granule cells (2009, positive): “…an activity-dependent survival mechanism specific to this later phase of granule cell maturation comes from the previous finding that the loss of NMDA receptors decreases granule cell survival between 14 and 21 days after cell birth but has no effect between 7 and 14 days (Tashiro et al., 2006).”
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. (2007, positive): “This is similar to the role we propose here for NLs, and is necessary for the synaptic integration of newly generated neurons in the adult dentate gyrus (Tashiro et al., 2006).”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “The survival of newborn neurons can also be influenced by the experience of animals, such as spatial learning and exposure to an enriched environment (Tashiro et al., 2006, 2007).”
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, positive): “Concentrated viral solutions were prepared by cotransfection of retroviral vectors and VSV-G (envelope vector) into HEK293T cells, followed by ultracentrifugation of viral supernatant as described (Tashiro et al., 2006b).”
Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases (2013, methodology): “Tashiro et al. showed that NMDAR-driven excitation is critical for survival and integration of newborn neurons using retrovirus-mediated single-cell knockout of NMDAR in adult-born hippocampal neurons, (Tashiro et al., 2006).”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, methodology): “NMDA receptor activation plays a role in the selection of newborn neurons for survival during the third week after neuronal birth (Tashiro et al., 2006b).”
Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus (2012, background): “Indeed survival of newborn neurons is dependent upon their input synaptic activity (10); interestingly, newborn neurons lacking the full-length TrkB receptor show impaired synaptic plasticity and therefore an increased death rate at the transition from the immature to the mature stage (8).”
Adult neurogenesis and the plasticity of the dentate gyrus network (2011, background): “…Societies and Blackwell Publishing Ltd European Journal of Neuroscience, 33, 1055–1061 notion, retrovirus-mediated single-cell gene knockout has revealed a striking decrease in the survival of newborn DGCs when NMDA receptor function was impaired in a cell-autonomous fashion (Tashiro et al., 2006).”
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, background): “After an activity-dependent selection process, newborn granule cells integrate into the preexisting dentate circuitry (van Praag et al. 2002; Kempermann et al. 2003; Tashiro et al. 2006).”
Synapse formation on neurons born in the adult hippocampus (2007, background): “In support of this possibility, we recently showed that the survival of new neurons is mediated by the expression of NMDA receptor, in a cell-specific manne”