Kinesin transports RNA: isolation and characterization of an RNA-transporting granule.

By Y. Kanai, N. Dohmae, N. Hirokawa. Neuron, 2004

1,131 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1661c789f994562b0db7a1f23d5e869199bacf4b

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Citations in the corpus

mRNA Localization: Gene Expression in the Spatial Dimension (2009, neutral): “The composition of these RNA granules differed somewhat from those identified by Kanai and colleagues (Kanai et al., 2004).”
Role of Purα in targeting mRNA to sites of translation in hippocampal neuronal dendrites (2006, background): “Here we demonstrate dramatic mislocalization, in PURA / mice, of Staufen and FMRP, proteins recently reported to be associated with Pura in processes of dendritic mRNA transport and translation (Ohashi et al., 2002; Kanai et al., 2004).”
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. (2008, neutral): “Although futsch (MAP1b) is one dFMRP target whose translational impairment is already known to account for the synaptic overgrowth phenotype in Drosophila (Zhang et al., 2001), it is unclear whether this is caused by loss of local translational regulation in axons.”
AXONAL TRANSPORT: CARGO-SPECIFIC MECHANISMS OF MOTILITY AND REGULATION (2014, background): “…proteins and direct transport to either dendrites or the axon (Holt and Schuman, 2013; Merianda et al., 2013). mRNA is transported as translationally repressed RNA granules along with RNA-binding proteins and ribosomes (Kanai et al., 2004; Knowles et al., 1996; Krichevsky and Kosik, 2001).”
Cell-Free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers Within Hydrogels (2012, methodology): “After subtracting 54 ribosomal proteins, the remaining 106 proteins were compared with a data set of all proteins reported in the literature to be associated with stress granules, neuronal granules, processing bodies, and polar granules (Buchan and Parker, 2009; Elvira et al., 2006; Kanai et al., 20”
BDNF-induced local protein synthesis and synaptic plasticity. (2014, neutral): “associated granules described by Hirokawa and coworkers (Kanai et al., 2004).”
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. (2010, positive): “KIF5 binds to mRNA-containing complexes in dendrites (Kanai et al., 2004; Ling et al., 2004; Mallardo et al., 2003; Ohashi et al., 2002).”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “Downregulation of members of the kinesin family impairs the ability of RNAs to translocate in neurites (Carson et al., 1998; Kanai et al., 2004).”