Nitric oxide, oxidants, and protein tyrosine nitration

By Rafael Radi. Proceedings of the National Academy of Sciences of the United States of America, 2004

1,463 citations recorded by the source corpus.

Subfields: Biophysics, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/163ed797274f311e4b50db52cbecbb77017c65a1

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Citations in the corpus

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. (2018, background): “In turn, peroxynitrite promotes protein nitration and contributes to dysfunction and death of endothelial cells [19-21].”
Antioxidants and Antioxidant Enzymes in Higher Plants (2018, background): “Peroxynitrite (ONOOH) is generated in cells by the spontaneous reaction of nitric oxide (•NO) with the superoxide anion and can mediate nitration of tyrosine residues in proteins and fatty acids, causing cellular dysfunctions (Radi 2004; Chaki et al. 2015; Mata-Pérez et al. 2016).”
Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine (2018, background): “other nitrating systems can be disclosed experimentally (87).”
Regulation of immune responses by L-arginine metabolism (2005, background): “These highly reactive oxidizing agents damage biological target”
Peroxynitrite, a Stealthy Biological Oxidant* (2013, background): “Usually, the metal-based Lewis adducts undergo homolysis to yield NO2 and the corresponding oxyradical-metal complex, which rearranges to a strongly oxidizing oxo-metal complex (13, 23) (Equation 9).”
Chemical biology of peroxynitrite: kinetics, diffusion, and radicals. (2009, background): “Despite the fact that in vivo effects of FePorphyrins have been observed in a number of models and that most of the effects are routinely attributed to peroxynitrite scavenging, it is not clear whether isomerizaMnIIITM-2-PyP5 ONOO → OAMnIVTM-2-PyP4 ●NO2(5) OAMnIVTM-2-PyP4 RdH H → MnIIITM-2-PyP5 ●RD ”
Nitroaromatic Compounds, from Synthesis to Biodegradation (2010, background): “radicals and, in some cases, to the activity of nitric oxide synthase (97, 116, 154, 205).”