ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

By K. Wellen, G. Hatzivassiliou, U. Sachdeva, Thi V Bui, J. Cross, Craig B. Thompson. Science, 2009

2,089 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1624799ebc50ae7fe35023c5fe7499d11b9099eb

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In Geriatrics and Gerontology

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Citations in the corpus

Mitochondrial metabolism and cancer (2017, background): “Besides fueling the oxidative mode of the TCA, citrate can also be converted into acetyl-CoA for export to the cytoplasm and nucleus [4, 81], where it can either be employed for fatty acid and cholesterol synthesis (to support the membrane need associated with intense proliferation) or used for acet”
IDH mutation impairs histone demethylation and results in a block to cell differentiation (2012, methodology): “In brief, 3T3-L1 cell differentiation, Oil-Red-O staining, and in vitro histone demethylase assay were performed as previously describe”
Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming (2011, background): “A glycolytic burst could promote linkage of energy metabolism with nuclear reprogramming-induced epigenetic resetting (Huangfu et al., 2008; Friis et al., 2009; Wellen et al., 2009; Teperino et al., 2010), priming the cell for pluripotent induction.”
Metabolic Regulation of Gene Expression by Histone Lysine β-hydroxybutyrylation (2016, positive): “It is believed that histone post-translational modifications (PTMs), such as lysine acetylation and methylation, provide a means of adapting to these challenges to maintain physiological homeostasis (Wellen et al., 2009).”
Metabolic control of cell death (2014, background): “A nuclear isoform of citrate lyase is required for the acetylation of histones and other proteins (70).”
The world of protein acetylation. (2016, background): “Glucose availability was accompanied by increases in glycolytic gene expression [323].”
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (2013, background): “Interestingly, as well as being essential for FA synthesis, ACLY is also an essential regulator of histone acetylation, thereby linking cellular metabolism to the regulation of gene expression (Wellen et al., 2009).”
Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes (2011, background): “As protein acetylation has also been linked to metabolism in several previous studies (Choudhary et al., 2009; Friis et al., 2009; Takahashi et al., 2006; Wang et al., 2010; Wellen et al., 2009; Zhao et al., 2010), we predict that a similar control of gene expression and protein activities with resp”