Uniform Inhibition of Dopamine Neurons in the Ventral Tegmental Area by Aversive Stimuli

By Mark A. Ungless, P. Magill, J. Bolam. Science, 2004

809 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1587608e56fee40d2b7e75fb815a6e4da6e22961

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Performance Monitoring in the Anterior Cingulate is Not All Error Related: Expectancy Deviation and the Representation of Action-Outcome Associations (2007, background): “This view is supported by single-cell recordings showing that dopamine neurons are activated by salient stimuli that signal the need for behavioral change regardless of the valence of the stimuli (Horvitz, 2000; also see Ungless, 2004; Ungless, Magill, & Bolam, 2004 ), by evidence from microdialysi”
Behavioral theories and the neurophysiology of reward. (2006, background): “In anesthetized animals, dopamine neurons show depressions following painful stimuli (Schultz & Romo 1987, Ungless et al. 2004).”
The debate over dopamine’s role in reward: the case for incentive salience (2007, background): “Thus, there is a degree of generality in dopamine functions, even if dopamine neurons fire more to positive rewards than to aversive events (Levita et al. 2002; Mirenowicz and Schultz 1996; Ungless et al. 2004).”
Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input–Output Mapping (2015, background): “Initial in vivo electrophysiological studies suggested that midbrain DA neurons were a homogenous population, uniformly excited by rewards or reward-predictive cues and unaffected or transiently inhibited by aversive events (Mirenowicz and Schultz, 1996; Ungless et al., 2004).”
Leptin receptor signaling in midbrain dopamine neurons regulates feeding. (2006, positive): “Dopamine neurons were identified by use of characteristic electrophysiological properties (Henry et al., 1989; Marinelli et al., 2006; Marinelli and White, 2000; Ungless et al., 2004; see Experimental Procedures for details), and anatomical placement was confirmed by histological analysis (Figure ”
The basal ganglia: learning new tricks and loving it. (2005, background): “Aversive stimuli do not appear to activate dopamine-containing neurons (in the rat ventral tegmental area) [26]; and in Parkinson’s disease patients, dopamine agonist treatment improves learning with positive reinforcers but not learning with negative reinforcers [27 ].”
Multiple Forms of Value Learning and the Function of Dopamine (2009, background): “Single-unit studies have generally failed to observe strong dopaminergic activity in response to aversive events (Schultz, 1998), and indeed it has been found that dopamine neurons may in fact be inhibited in responding during aversive stimulation such as tail pinch in rats (Ungless et al., 2004).”
Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli (2009, background): “In addition, we have reported that dopamine neurons are uniformly inhibited by aversive stimuli, which is consistent with reward theories; a separate group of VTA neurons that are excited by noxious stimuli are not dopaminergic (6).”
The short-latency dopamine signal: a role in discovering novel actions? (2006, background): “It is therefore significant that recent reports indicate that noxious stimuli elicit a short-latency (”
Multiple dopamine functions at different time courses. (2007, background): “F or p er so na l u se o nl y. several seconds (Schultz & Romo 1987, Mantz et al. 1989, Ungless et al. 2004).”
Cortico-Basal Ganglia Reward Network: Microcircuitry (2009, positive): “It is therefore in a critical position to inhibit DA cell firing in response to aversive stimuli (Grace and Bunney, 1979; Ungless et al, 2004; Jhou et al, 2009a) or when expected rewards are not delivered (Schultz, 1998b).”