Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.

By Lin Zhang, J. Conejo-Garcia, D. Katsaros, P. Gimotty, M. Massobrio, G. Regnani, A. Makrigiannakis, H. Gray, K. Schlienger, M. Liebman and 2 more. New England Journal of Medicine, 2003

3,391 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/150e3deda6b8428ec4d1659ff005757268bba2f5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Lieping Chen
2. W. Zou
3. D. Pardoll
4. J. Wolchok
5. V. Bronte
6. S. Topalian
7. Janis Taube
8. George Coukos

In Oncology

1. Lieping Chen
2. W. Zou
3. D. Pardoll
4. J. Wolchok
5. S. Topalian
6. Janis Taube
7. Charles G. Drake
8. D. Tuveson

Citations in the corpus

• Cancer and the chemokine network (2004, result): “5%) in patients whose tumour biopsy samples contained CD3 + tumour- infiltrating lymphocytes compared with patients whose biopsy samples lacked these cell”
• Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function (2006, background): “A direct correlation exists between the number of tumor-infi ltrating lymphocytes (TILs) and a favorable clinical outcome, as demonstrated in patients with metastatic ovarian cancer (20).”
• From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review) (2018, neutral): “It has been proposed that four different types of tumor microenvironment exist based on the presence or absence of TILs and PD‑L1 expression (34).”
• Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma (2013, background): “18 Similar favorable clinical outcomes in the presence of TILs have been observed with other solid tumors including ovarian, esophageal, small cell lung, and colorectal cancers (22-25).”
• Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. (2005, neutral): “Old, October 27, 2005 In a recent report, [Zhang et al. (2003) N. Engl.”
• Rethinking Ovarian Cancer: Recommendations for Improving Outcomes (2011, neutral): “The increased infiltration of lymphocytes in tumour islets predicts significantly longer survival in ovarian cance”
• Prognostic Significance of Tumor-infiltrating T-cells in Ovarian Cancer: a Meta-analysis (2011, background): “Definitive studies are needed to dissect the potential mechanisms through which effective TILs can control tumor growth, but direct cytotoxic effect on tumor cells as well as a potent antiangiogenic effect of angiostatic cytokines such as interferon-gamma, and chemokines such as interferoninducible ”