Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.

By E. Sato, S. Olson, Jiyoung Ahn, B. Bundy, H. Nishikawa, F. Qian, A. Jungbluth, D. Frosina, S. Gnjatic, C. Ambrosone and 8 more. Proceedings of the National Academy of Sciences of the United States of America, 2005

2,404 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/ca4f2ce172bf5807c711aa05efa080dd6f1684cf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. James P. Allison
2. Guido Kroemer
3. L. Zitvogel
4. G. Dranoff
5. N. Restifo
6. S. Rosenberg
7. J. Wolchok
8. George Coukos

In Oncology

1. James P. Allison
2. L. Zitvogel
3. Guido Kroemer
4. J. Wolchok
5. N. Restifo
6. S. Rosenberg
7. G. Dranoff
8. G. Freeman

Citations in the corpus

• Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells (2011, background): “…CD8+ T lymphocytes and Foxp3+/CD4+ T reg lymphocytes was correlated with the effect of immunotherapy on experimental melanoma (Quezada et al., 2006), and a high CD8+/T reg cell ratio was found to be associated with a favorable prognosis in human epithelial ovarian cancer (Sato et al., 2005).”
• Adoptive immunotherapy for cancer: building on success (2006, result): “, although these findings have been recently contradicte”
• Prognostic Significance of Tumor-infiltrating T-cells in Ovarian Cancer: a Meta-analysis (2011, result): “In the three studies where results for both CD3 and CD8 were reported [24,30,32], the reported HRs showed the same direction of association (all >1) but were less significant for the CD3 markers.”
• Tumor-infiltrating NY-ESO-1–specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer (2010, background): “In epithelial ovarian cancer (EOC), support for the role of immune surveillance of tumors comes fromobservations indicating that the presence of intraepithelial CD8-infiltrating T lymphocytes in tumors is associated with improved survival of patients with the disease (2).”
• The biology of ovarian cancer: new opportunities for translation (2009, background): “5% for patients who have tumours that lack T cell infiltrate”
• Rethinking Ovarian Cancer: Recommendations for Improving Outcomes (2011, positive): “Conversely, the detection of high numbers of T regulatory cells, which mediate immune suppression, predicts poor patient surviva”