Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation
By M. Seibenhener, J. Babu, T. Geetha, H. Wong, N. Krishna, M. W. Wooten. Molecular and Cellular Biology, 2004
745 citations recorded by the source corpus.
Subfields: Epidemiology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/1497f15be59425bdefba3d438495d34d7a1418da
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
- Ivan Dikic
- A. Cuervo
- Susmita Kaushik
- Esther Wong
- S. Martens
- Gabriele Zaffagnini
- I. Novak
- David G. McEwan
In Molecular Biology
In Oncology
Citations in the corpus
- HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagy (2010, background): “This activity is likely mediated by another ubiquitin-binding protein, p62, which binds to LC3 with high affinity and promotes protein aggregate clearance (Seibenhener et al, 2004; Bjorkoy et al, 2005).”
- p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation (2016, neutral): “Some observations suggest that loss of p62 leads to cortactin–F-actin assemblies remaining localized in the periphery and ubiquitinated protein accumulation [85].”
- A role for ubiquitin in selective autophagy. (2009, background): “Intriguingly, p62 has also been suggested to directly interact with the proteasome (Seibenhener et al., 2004), which raises the question whether autophagy receptors may have a more direct role in proteasomal degradation of ubiquitinated proteins.”
- Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. (2011, background): “TF-p62-D69A and TF-p62-D69A-S403A showed undetectable levels of coeluted K48-branched polyUb, but significant binding to K63-linked chains as previously reported (Long et al., 2008; Seibenhener et al., 2004; Wooten et al., 2008).”
- Ubiquitination and selective autophagy (2012, background): “Furthermore, p62 is required for the concentration of ubiquitinated proteins forming aggregates and crucial for their clearance.(6,62)”
- Mechanisms of Selective Autophagy (2016, positive): “The human cargo receptor p62/SQSTM1 mediates the degradation of ubiquitinated cargo material such as aggregated proteins or cytosolic bacteria [44 – 47]. p62 binds ubiquitin with a relatively low affinity.”