The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

By R. Pola, L. Ling, Marcy Silver, M. Corbley, M. Kearney, R. Pepinsky, R. Shapiro, F. Taylor, D. Baker, T. Asahara and 1 more. Nature Medicine, 2001

666 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/14507d12048e0e274b224dfbab63c57dd69a09ae

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Citations in the corpus

• Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis (2014, neutral): “Shh alsomediates proangiogenic signaling by upregu- lating VEGF expression (Pola et al., 2003; Pola et al., 2001) and VEGF can induce expression of the Hh transcriptional activator Gli1 (Goel and Mercurio, 2013), suggesting the possible exis- tence of a positive feedback loop.”
• Hedgehog: functions and mechanisms. (2008, background): “In addition to targeting tumors that themselves have hyperactive Hh pathways, antagonists of the Hh pathway could also affect growth of tumors that use Hh ligands to induce angiogenesis (Pola et al. 2001; Nagase et al. 2008) or recruit other types of stromal cells supporting tumor growth.”