Predominant Autoantibody Production by Early Human B Cell Precursors

By Hedda Wardemann, S. Yurasov, A. Schaefer, James W. Young, E. Meffre, Michel C. Nussenzweig. 2003

2,032 citations recorded by the source corpus.

Subfields: Immunology, Radiology, Nuclear Medicine and Imaging

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In Immunology

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Cellular and genetic mechanisms of self tolerance and autoimmunity (2005, background): “TCR tolerance mechanisms in central lymphoid organs: (4) TCR -chain editing by V(D)J recombination; (5) Death and deletion of semi-mature T cells.”
Igκ allelic inclusion is a consequence of receptor editing (2007, background): “Despite these mechanisms of tolerance, autoantibodies are frequently detected in normal mice (7, 8), and recent estimates suggest that up to 20% of long-lived B cells are self-reactive in humans (9).”
Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool. (2013, methodology): “It is estimated that during early development 50–75% of B cells produce self-reactive antibodies, half of them being polyreactive (Wardemann et al., 2003; Tiller et al., 2007).”
Comprehensive mapping of immune perturbations associated with severe COVID-19 (2020, background): “Age 36 (24-61) 30 (20-49) 59 (29-64) 68 (38-81)”
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells (2020, neutral): “On the other hand, single-cell RT-PCR combined with fluorescence-activated cell sorting (FACS) or optofluidics platform, such as Beacon (Berkley Light), could obtain antibody sequences in several days by performing nested PCR on single antigen-binding memory B cells after single-cell sorting (Tiller”
The regulation of IgA class switching (2008, background): “An additional human B-cell subset that is possibly involved in T-cell-independent IgA responses is the transitional B-cell subset, which expresses polyreactive antibodies encoded by unmutated V(D)J gene”
Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires (2016, background): “Antibodies having highly positively charged CDR3s are more likely to be autoreactive, and B cells encoding positively charged CDR3s are known to be eliminated at distinct developmental checkpoints in bone marrow (18).”
The double life of a B-1 cell: self-reactivity selects for protective effector functions (2011, background): “, whereas autoreactive and polyreactive BCRs are enriched for long CDR3 sequence”
Toll-like receptors in systemic autoimmune disease (2006, background): “Autoantibodies are produced by self-reactive B cells, which most probably constitute a reasonably high percentage (5-20%) of the naive B-cell repertoire in most individuals 35 .”