Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

By Hadi M. Yassine, J. Boyington, P. McTamney, Chih-Jen Wei, M. Kanekiyo, W. Kong, J. Gallagher, Lingshu Wang, Yi Zhang, M. Joyce and 10 more. 2015

672 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Radiology, Nuclear Medicine and Imaging

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Citations in the corpus

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus (2019, background): “In all cases, immunogenicity of the antigen was increasedbymultivalent presentation, and in somecases, an epitope-focusingeffectwasobserved inwhichpotent neutralizing epitopeswere preferentially targeted (Duan et al., 2018; Kanekiyo et al., 2015; Yassine et al., 2015).”
A Hemagglutinin Stem Vaccine Designed Rationally by AlphaFold2 Confers Broad Protection against Influenza B Infection (2022, background): “Trimeric HA stem or HA stem nanoparticles were also explored to generate stem-specific antibodies with protective activity [11].”
Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses (2020, background): “Immunization: 2-based HA stem immunogens convincingly elicit protective antibody responses that overcome the group boundary in animal models [32] [33] [34] 40 .”
Self-assembling protein nanoparticles in the design of vaccines (2015, positive): “…software (The PyMOL Molecular Graphics System, Version 1.7.6.2, Schrödinger, LLC). stem region of the H1 HA glycoprotein, yet was capable of evoking broadlycross-reactiveantibodiesthat,incontrasttoplainnanoparticles, protected mice and ferrets against lethal doses of heterosubtypic H5N1 virus [94].”
HIV-1 envelope trimer fusion proteins and their applications (2016, positive): “For example, fusing eight influenza hemagglutinin (HA) trimers or engineered HA stem antigens to Helicobacter pylori ferritin greatly improved NAb responses against influenza in animals [12,13].”
Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages (2018, neutral): “534 Pseudovirus neutralization assays 535 Lentivirus-based pseudoviruses displaying influenza HA and NA were produced as previously 536 described (17).”
Quantifying B cells capable of producing broadly neutralizing antibodies against influenza serves as a metric to guide the development of a universal influenza vaccine (2016, positive): “…immunization with a divergent influenza (Figures 6A and 7F), likely by enhancing immune focus to the HA stem (Figures 7G and 7H), an approach utilized by ‘‘stem-only’’ or ‘‘headless’’ immunogens (Impagliazzo et al., 2015; Yassine et al., 2015) and by chimeric HA immunogens (Krammer et al., 2015).”
Next-Generation Influenza Vaccines. (2020, background): “2015), or displayed on nanoparticles (Yassine et al. 2015; Corbett et al. 2019) were shown to be efficacious, then these products could be produced and stockpiled and be available for deployment against any emerging influenza A virus threat.”
New Vaccine Design and Delivery Technologies (2019, background): “Common strategies include designing disulfide bonds to immobilize linked domains [28] [29] [30] [31] [32] , improved hydrophobic packing to stabilize a particular conformational state [22, 33] , proline mutations to constrain conformational flexibility, and proline/glycine mutations to discourage he”
Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines (2020, methodology): “Additional studies will be required to determine if this observation holds for mosaic and cocktail immunogens displaying different combinations of HAs and antigens other than HA.”
Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles (2016, positive): “The 24-meric ferritin (FR) nanoparticle (12.2 nm in diameter) has been used to present the hemagglutinin (HA) of inﬂuenza 32,33 , gp350 of Epstein–Barr virus 32 and scaffold antigens designed for HIV-1 and hepatitis C virus 34,35 .”
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen (2017, background): “Notably, the identification of stem-directed antibodies against influenza HA (35) represented a paradigm shift in the approach to develop a universal influenza vaccine, with recent studies demonstrating substantial promise (33, 34).”
Next-generation influenza vaccines: opportunities and challenges (2020, neutral): “(left) reprinted from reF.(118), Springer Nature Limited.”
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers (2020, background): “As a result, there have been numerous attempts to refocus the immune response to these conserved epitopes [11-16].”