New Vaccine Design and Delivery Technologies

By M. Kanekiyo, Daniel Ellis, Neil P. King. 2019

60 citations recorded by the source corpus.

Abstract Technological advances in immunology, protein design, and genetic delivery have unlocked new possibilities for vaccine concepts and delivery technologies that were previously inaccessible. These next-generation vaccine design efforts are particularly promising in their potential to provide solutions to challenging targets for which conventional approaches have proven ineffective—for example, a universal influenza vaccine. In this perspective, we discuss emerging approaches to vaccine design and engineering based on recent insights into immunology, structural biology, computational biology, and immunoengineering. We anticipate that these cutting-edge, interdisciplinary approaches will lead to breakthrough vaccine concepts for ever-evolving and (re)emerging influenza viruses, with important ramifications for global public health.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Infectious Diseases

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Barney S. Graham
2. Ralph S. Baric
3. A. Walls
4. D. Veesler
5. M. Kanekiyo

In Infectious Diseases

1. D. Veesler
2. A. Walls
3. Ralph S. Baric

Citations in the corpus

• Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2 (2020, positive): “Vaccine development efforts responding to the COVID-19 pandemic have made extensive use of platform technologies for antigen design, antigen display, and vaccine delivery (Kanekiyo et al., 2019a).”
• Next-Generation Influenza Vaccines. (2020, background): “This reduces the frequency of responses intolerant to variability and increases the chances for amplifying B cells that tolerate antigenic variation and, hence, subvert the immunodominance (Kanekiyo et al. 2019b).”