Mitochondrial dysfunction and molecular pathways of disease.

By S. Pieczenik, J. Neustadt. Experimental and molecular pathology (Print), 2007

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Myalgic encephalomyelitis: International Consensus Criteria (2011, background): “Myalgic encephalomyelitis (ME), also referred to in the literature as chronic fatigue syndrome (CFS), is a complex disease involving profound dysregulation of the central nervous system (CNS) [1-3] and immune system [4-8], dysfunction of cellular energy metabolism and ion transport [9-11], and cardi”
Mitochondrial dysfunction and oxidative stress in metabolic disorders - A Step towards mitochondria based therapeutic strategies (2016, background): “Mitochondrial dysfunction is defined as diminished mitochondrial biogenesis, altered membrane potential, and the decrease in mitochondrial number and altered activities of oxidative proteins due to the accumulation of ROS in cells and tissues [89].”
Oxidant Mechanisms in Renal Injury and Disease (2016, neutral): “NADPH oxidases, along with the mitochondria, are the major producers of superoxide and are the principal sources of abnormal cellular signaling (205, 236, 262).”
A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise. (2013, background): “High concentrations of mitochondria are found in the brain which increases its vulnerability to reductions in aerobic metabolism (Pieczenik and Neustadt, 2007).”