Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation

By Meenakshi K. Doma, R. Parker. Nature, 2006

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Learning the sequence determinants of alternative splicing from millions of random sequences. (2015, background): “These results indicate that a large string of amino acids translated out of frame will destabilize the mRNA, likely through the no-go decay pathway (Doma and Parker, 2006; Shoemaker et al., 2010) as ribosomes stall due to protein misfolding.”
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. (2007, background): “Also like NMD in D. melanogaster, the resulting free end of the 5 -cleavage product is degraded by the exosome, and the resulting free end of the 3 -cleavage product is degraded by Xrn1.”
RNA-quality control by the exosome (2006, background): “Furthermore, the exosome degrades the 5′ fragments of mRNAs that are cleaved in the no-go decay pathway, which targets mRNAs on which translation has stalle”
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. (2012, background): “A second quality control system for mRNA translation is referred to as no-go decay (NGD) and leads to endonucleolytic cleavage of mRNAs with strong stalls in translation elongation (Doma and Parker 2006; reviewed in Harigaya and Parker 2010).”