Neurobiology of schizophrenia

By Godfrey D. Pearlson. 2000

914 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Psychiatry and Mental health, Philosophy

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Citations in the corpus

Visual Feature Attribution Using Wasserstein GANs (2017, background): “In clinically oriented research, identifying subject-speciﬁc disease effects would be useful for stratiﬁcation amongst the patient population and to help disentangling diseases such as AD [25] and Schizophrenia [48], that are believed to be composed of multiple sub-types rather than a single disease”
Distinct functions of the two isoforms of dopamine D2 receptors (2000, neutral): “D2 receptors are also known targets of antipsychotic drugs that are used to treat neuropsychiatric disorders such as schizophreni”
Dynamic functional connectivity analysis reveals transient states of dysconnectivity in schizophrenia (2014, background): “Despite the large body of evidence showing aberrant brain structural and functional connectivity in schizophrenia (Breakspear et al., 2003; Calhoun et al., 2011; Friston, 1998; Pearlson and Marsh, 1999; Pearlson, 2000), there is a lack of consistency of observed functional connectivity differences i”
A method for functional network connectivity among spatially independent resting-state components in schizophrenia (2008, background): “In addition, reduced fluctuations in frontal and parietal regions have been attributed as a possible concomitant of deficit symptoms in schizophrenia (Pearlson, 2000).”
To Model a Psychiatric Disorder in Animals: Schizophrenia As a Reality Test (2000, neutral): “It is clear that most psychiatric disorders, including schizophrenia, are multifactorial, [i.e., multiple genes interact with multiple environmental factors to create a particular phenotype (Egan and Weinberger 1997)].”
Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives (2007, background): “Other candidate genes in this respect are Disc 1 (Cannon et al. 2005 ; Porteous et al. 2006 ; Ross et al. 2006) and brainderived neurotrophic factor (Bath & Lee, 2006), both related to susceptibility to schizophrenia as well as bipolar disorder on the one hand, and cognitive dysfunction (executive…”
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. (2007, background): “1154 Cell 130, 1146–1158, September 21, 2007 a2007 Elsevie DISC1 in the normal developing and adult brain and its roles in these mental illnesses are not well understood (Ishizuka et al., 2006; Porteous and Millar, 2006; Ross et al., 2006).”
Automated apparatus for quantitation of social approach behaviors in mice (2004, background): “Social phobias and social anxiety are defined by avoidance of social situations (Bell et al. 1999; Marcin & Nemeroff 2003; Stein & Deutsch 2003; Tancer & Uhde 1997) and social dysfunction is a component of schizophrenia (Carpenter 1993; Dworkin 1992; Egan & Weinberger 1997; Morrison & Bellack 1987”
Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. (2002, neutral): “In addition to the still rather diffuse dopaminergic and developmental “hypotheses” of schizophrenia, both the glutamatergic and GABA-ergic systems have been implicated (Goldman-Rakic and Selemon 1997; Benes 2000; Pearlson 2000), and these four areas of investigation already overlap considerably.”
DISC1 regulates neural progenitor proliferation via modulation of GSK3β/β-catenin signaling (2009, background): “Modulation of GSK3b/b-Catenin Signaling”