Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

By J. Shiver, T. Fu, Ling Chen, D. Casimiro, M. Davies, R. K. Evans, Zhi-Qiang Zhang, A. Simon, W. Trigona, S. Dubey and 42 more. Nature, 2002

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Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes (2002, background): “jpg" NDATA ITEM> ]> Potent virus-specific cytotoxic T lymphocyte (CTL) responses elicited by candidate AIDS vaccines have recently been shown to control viral replication and prevent clinical disease progression after pathogenic viral challenges in rhesus monkey”
DNA vaccines: ready for prime time? (2008, methodology): “The poloaxmer CRL1005 has been successful in preclinical models for simian HIV vaccine strategie”
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major (2007, background): “elicit strong T-cell responses and have potentially broad application for use in HI”
T-cell quality in memory and protection: implications for vaccine design (2008, background): “Importantly, there may be major differences in the magnitude and quality of the T-cell responses induced by rADV-5 and poxvirus vector”
Adenoviruses as vaccine vectors (2004, neutral): “623 TABLE 2 Pathogen Animal model Insert Immune response References Human immunodeficiency virus/simian immunodeficiency virus Rodent, NHP, human Gag, Pol, Nef, Env CMI and antibody [31,73,89,90,107–109 Rabies virus Rodent, dog Glycoprotein CMI and antibody [40,68,70,71,93,94, 110–112] Dengue virus ”