Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes

By D. Barouch, J. Kunstman, M. Kuroda, J. Schmitz, S. Santra, F. Peyerl, G. Krivulka, Kristin R. Beaudry, M. Lifton, D. Gorgone and 4 more. Nature, 2002

731 citations recorded by the source corpus.

Subfields: Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/85e8340314d374a304eb944fe6e74ac02fe26586

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. E. Wherry
2. Rafi Ahmed
3. S. Kaech
4. A. Schietinger
5. P. Greenberg
6. Bali Pulendran
7. M. Bevan
8. G. Freeman

In Virology

1. Rafi Ahmed

Citations in the corpus

• Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment (2003, background): “However, even when the level of persistent viral replication is low, epitope escape mutants can arise and result in a loss of immune control (11).”
• Comprehensive Epitope Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses Directed against the Entire Expressed HIV-1 Genome Demonstrate Broadly Directed Responses, but No Correlation to Viral Load (2003, background): “The selective immune pressure mediated by CD8 T cells on the viral genome has been further supported by studies demonstrating viral escape from CD8 -cytotoxic T-cell (CTL)-mediated immune pressure in HIV-1 and SIV infection (3, 9, 14, 23, 24, 40).”