Histone H2A.Z Regulates Transcription and Is Partially Redundant with Nucleosome Remodeling Complexes

By M. Santisteban, T. Kalashnikova, M.Mitchell Smith. 2000

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Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin. (2003, neutral): “absence of the SWI/SNF ATP-dependent nucleosome remodeling complex (Santisteban et al., 2000).”
Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. (2005, background): “Z at the promoter regions of the highly inducible GAL1–10 and PHO5 genes in yeast (Santisteban et al., 2000).”
Dynamic regulation of nucleosome positioning in the human genome. (2008, neutral): “Z appears to be preferentially lost upon induction of the Pho5 gene (Santisteban et al., 2000).”
Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss. (2005, positive): “Some promoter occupancy was expected based on previous studies (Larochelle and Gaudreau, 2003; Santisteban et al., 2000 ), but the wide scope and Pol II specificity revealed in our analysis firmly establishes Pol II promoter occupancy as a general property of Htz1.”