Cell Migration: Integrating Signals from Front to Back

By A. Ridley, M. Schwartz, K. Burridge, R. Firtel, M. Ginsberg, Gary G. Borisy, J. Parsons, A. Horwitz. Science, 2003

5,203 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0f63732722a8437d5da8971a5f28b9e8e7dd6380

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Immunology and Allergy

In Molecular Biology

Citations in the corpus

Brain metastases: epidemiology and pathophysiology (2005, background): “Invasion has three major steps [55]: (1) The tumor cell attaches to the extracellular matrix of the host organ.”
Calcium in tumour metastasis: new roles for known actors (2011, background): “Such retraction is supported by myosin II contraction, which is regulated by myosin light-chain (MLC) phosphorylation through Ca 2+ -dependent MLC kinase (MLCK) and by disassembly of adhesions at the rear of the cell owing to calpain-mediated cleavage of focal adhesion proteins such as integrins, ta”
Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner (2008, neutral): “{ ( ) { { { actin actin growth rate of change diasassembly retrograde flow of F-actin relative to the density leading edge f f Vb x hf V t x ! ! = " " ! ! (2)”
CDK inhibitors: cell cycle regulators and beyond. (2008, positive): “p21-activated kinase (PAK) induce actin rearrangements that control the formation of lamellipodia and new focal contacts at the cell edges (Ridley et al., 2003).”
Imaging Native β-Actin mRNA in Motile Fibroblasts (2004, background): “The cells control the rates of polymerization and depolymerization of actin monomers, and the degree of branching in the actin filaments, to accomplish the protrusion of lamellipodia (Mitchison and Cramer, 1996; Pollard and Borisy, 2003; Ridley et al., 2003).”
Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis (2010, background): “Cell migration is a dynamic and multistep process of leading edge protrusion, turnover of focal adhesions, generation of tractional forces, and tail retraction and detachment [3,4].”
Collective cell migration in morphogenesis, regeneration and cancer (2009, background): “jpg" NDATA ITEM> ]> The migration of single cells is the best-studied mechanism of cell movement in vitro and is known to contribute to many physiological motility processes in vivo , such as development, immune surveillance and cancer metastasi”
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, background): “For instance, migration on 2D surfaces iteratively progresses through several steps: extension of the leading edge, adhesion formation, traction generation and subsequent retraction of the trailing edge (Lauffenburger and Horwitz, 1996; Ridley et al., 2003).”
The physics of cancer: the role of physical interactions and mechanical forces in metastasis (2011, neutral): “Much of what we have learned about the physical and molecular mechanisms driving normal and cancer cell motility has come from in vitro studies using two-dimensional (2D) substrate”
Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “Attachment to the extracellular matrix is mainly performed via transmembrane receptors which allow the communication between the ECM and the internal actin cytoskeleton as well as the cell contraction and movement [30].”
Dynamic Partitioning into Lipid Rafts Controls the Endo-Exocytic Cycle of the αL/β2 Integrin, LFA-1, during Leukocyte Chemotaxis (2005, background): “Directional migration involves the establishment and maintenance of a spatial and functional asymmetry of adhesion- and migration-related molecular components between the anterior (leading) and posterior (trailing) edges of the migrating cell (Lauffenburger and Horwitz, 1996; Ridley et al., 2003).”