Autophagy maintains stemness by preventing senescence

By Laura Garcia-Prat, Marta Martínez-Vicente, Eusebio Perdiguero, L. Ortet, J. Rodríguez-Ubreva, E. Rebollo, Vanessa Ruiz-Bonilla, Susana Gutarra, Esteban Ballestar, A. Serrano and 2 more. Nature, 2016

1,230 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/0f1f62970507610009e1575bfaaabc63eeeeff83

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Guido Kroemer
2. Frank Madeo
3. F. Pietrocola
4. Jesús Gil
5. Luigi Ferrucci
6. E. Fabbri
7. Beth Levine
8. L. Galluzzi

In Molecular Biology

1. S. Piccolo
2. F. Pietrocola
3. M. Cordenonsi
4. Frank Madeo
5. Guido Kroemer
6. Jesús Gil
7. Luigi Ferrucci
8. T. Eisenberg

In Physiology

1. Jesús Gil
2. Guido Kroemer
3. Luigi Ferrucci
4. Eleanor M. Simonsick
5. Jodie Birch
6. F. Pietrocola

Citations in the corpus

• The mitophagy pathway and its implications in human diseases (2023, background): “279 This fi nding is somewhat surprising because mitophagy was formerly thought to be an effector pathway instead of senescence cause.”
• Hallmarks of Cellular Senescence. (2018, neutral): “It can degrade nonspecific (general autophagy) or specific (selective autophagy) targets [149].”
• Mitochondrial dysfunction in cell senescence and aging (2022, neutral): “In contrast, other studies show that impairment in autophagy pathways can induce premature senescence, possibly due to generation of ROS by mitochondrial dysfunction, which in turn activates p53 signaling in primary human fibroblasts (73) and in muscle stem cells (74).”
• Measuring biological aging in humans: A quest (2019, background): “…in recent literature, although most is derived from animal studies (Acosta et al., 2013; Chang et al., 2015; Childs, Li, & van Deursen, 2018; García-Prat et al., 2016; GonzalesEbsen, Gregersen, & Olsen, 2017; Hall et al., 2017; Herranz & Gil, 2018; Kang et al., 2015; Ligthart et al., 2016;…”
• YAP/TAZ at the roots of cancer (2016, background): “Perhaps also connected to their role as CSC determinants, recent evidence also suggests that, in some contexts, YAP/TAZ constantly rejuvenate cancer cells by promoting basal levels of autophagy to avoid senescence (Garcia-Prat et al., 2016; Song et al., 2015a), while still opposing cell death caused”
• Mechanisms and functions of cellular senescence. (2018, neutral): “In agreement with this, Garcia-Prat et al. showed that mitophagy contributes to the maintenance of muscle function during aging by preventing senescence in satellite cells (116).”
• Senescence and the SASP: many therapeutic avenues (2020, background): “Similarly, senescence is responsible for the age-related decline in muscle stem cell regenerative function (Garcia-Prat et al. 2016).”
• Spermidine in health and disease (2018, background): “Spermidine administration stimulates autophagy in aging yeast, flies, and worms (24) and in cultured mammalian cells (18, 19, 70).”