Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus.

By V. Lemaire, M. Koehl, M. Le Moal, D. Abrous. Proceedings of the National Academy of Sciences of the United States of America, 2000

1,107 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/0ec75991cc2707cd1341696dc15aef66c8afb66b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. M. Weinstock
2. Fred H. Gage
3. Chunmei Zhao
4. B. Leuner
5. E. Gould
6. M. Le Moal
7. Sonia J. Lupien
8. P. Lucassen

In Developmental Neuroscience

1. Fred H. Gage
2. E. Gould
3. B. Leuner
4. Chunmei Zhao
5. D. Abrous
6. Wei Deng
7. H. van Praag
8. R. Duman

In Neurology

1. Fred H. Gage
2. E. Gould
3. B. Leuner
4. H. van Praag
5. M. Weinstock
6. Chunmei Zhao
7. R. Duman
8. D. Abrous

Citations in the corpus

• Reduced Hippocampal Neurogenesis in Adult Transgenic Mice with Chronic Astrocytic Production of Interleukin-6 (2002, background): “Postnatal neurogenesis generally declines in response to noninjurious stressful conditions (Gould et al., 1997; Eisch et al., 2000; Lemaire et al., 2000), but the functional consequences of this decrement remain largely unknown.”
• Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness (2016, background): “Furthermore, several studies have demonstrated the negative impact of similar stress protocols on learning and memory (Lemaire et al. 2000; Lordi et al. 1997).”
• Structural Plasticity and Hippocampal Function (2010, background): “In both rodents and monkeys, exposure to prenatal stress results in a persistent dampening in the production of new neurons in adulthood (Coe et al. 2003, Lemaire et al. 2000).”
• Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice (2005, background): “In addition, exercise enhances hippocampal neurogenesis (van Praag et al., 1999a,b; Fabel et al., 2003; Farmer et al., 2004), a process that may contribute to cognition (Lemaire et al., 2000; Shors et al., 2001).”
• A computational principle for hippocampal learning and neurogenesis (2005, background): “Neurogenesis is suppressed by adrenal hormones (Gould et al., 1992), and stress (Gould et al., 1998; Lemaire et al., 2000; McEwen and Magarinos, 2001) as well as in depression (Jacobs et al., 2000), which is associated with a loss of hippocampal volume (MacQueen et al., 2003).”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Prenatal restraint stress also decreases proliferation of newborn cells in the adult hippocampus and is associated with decreased learning in rodents (Lemaire et al., 2000; Liu et al., 2000) and altered emotional states in nonhuman primates (Coe et al., 2003).”
• Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons (2007, background): “Third, learning-induced apoptosis is followed by an increase in cell proliferation that provides the hippocampus with a new pool of young neurons [16,20].”
• Stress and adult neurogenesis (2006, background): “Restraint stress of pregnant rats and acoustic startle stress of pregnant macaques produce a lasting suppression of cell proliferation in the DG of the offspring (Lemaire et al., 2000; Coe et al., 2003).”