An operational definition of epigenetics.

By S. Berger, Tony Kouzarides, R. Shiekhattar, A. Shilatifard. Genes & Development, 2009

1,829 citations recorded by the source corpus.

A recent meeting (December 2008) regarding chromatin-based epigenetics was hosted by the Banbury Conference Center and Cold Spring Harbor Laboratory. The intent was to discuss aspects of epigenetic control of genomic function, and to arrive at a consensus definition of "epigenetics" to be considered by the broader community. It was evident that multiple mechanistic steps lead to the stable heritance of the epigenetic phenotype. Below we provide our view and interpretation of the proceedings at the meeting.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0ebbdc5f89245714002ad4c6d05ca905e5b4a2e2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Peter A. Jones
2. Manel Esteller
3. D. Reinberg
4. R. Margueron
5. G. Liang
6. Tony Kouzarides
7. M. Dawson
8. S. Baylin

Citations in the corpus

• Climate Change Impacts on Seagrass Meadows and Macroalgal Forests: An Integrative Perspective on Acclimation and Adaptation Potential (2018, background): “Epigenetic variations are molecular modifications that alter gene expression, but not the underlying DNA sequence, and occur in the form of histone modifications, non-coding RNAs, and DNAmethylations (Bossdorf et al., 2008; Berger et al., 2009).”
• TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019 (2019, background): “Epigenetics stands for qualitative and quantitative reversible changes in gene expression without affecting the DNA sequence itself [164].”
• Cancer epigenetics: from mechanism to therapy. (2012, background): “Despite decades of debate and research, a consensus definition of epigenetics remains both contentious and ambiguous (Berger et al., 2009).”
• Cancer epigenetics reaches mainstream oncology (2011, background): “But the word currently refers specifically to the study of mitotically and/or meiotically heritable changes in gene expression that occur without changes in the DNA sequenc”
• Traits to stay, traits to move: a review of functional traits to assess sensitivity and adaptive capacity of temperate and boreal trees to climate change (2016, background): “Epigenetic controls refer to stable, heritable phenotypes that result from changes in genetic expression without alterations to the DNA sequence (Berger et al. 2009).”
• Chromatin Structure and the Inheritance of Epigenetic Information (2010, background): “Although some histone PTMs are expected to contribute to the transmission of epigenetic information, others participate in the process of transcription — the so-called 'active marks' — and others are likely to be restricted to 'structural functions”
• Rethinking how DNA Methylation Patterns are Maintained (2009, background): “It has been far more difficult to decipher the mechanisms of epigenetic inheritance in somatic cells, and indeed there is still discussion as to what is encompassed by the term 'epigenetics' (Ref”