Positional Cloning of the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide

By U. Kim, E. Jorgenson, H. Coon, M. Leppert, N. Risch, D. Drayna. Science, 2003

859 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/0da858c322c03f478567be8ca0a2adc4a047d4de

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Peter Mombaerts
2. C. Zuker
3. N. Ryba
4. David A. Yarmolinsky

In Nutrition and Dietetics

1. Peter Mombaerts
2. C. Zuker
3. N. Ryba
4. David A. Yarmolinsky
5. Jayaram Chandrashekar

In Sensory Systems

1. Peter Mombaerts
2. N. Ryba
3. C. Zuker
4. David A. Yarmolinsky
5. Jayaram Chandrashekar

Citations in the corpus

• Common Sense about Taste: From Mammals to Insects (2009, background): “On the one hand, knockout (Mueller et al., 2005) or genetic alterations (Kim et al., 2003; Bufe et al., 2005) of specific T2Rs leads to changes in bitter taste sensitivity and selectivity.”
• The molecular receptive ranges of human TAS2R bitter taste receptors. (2010, background): “2005), some of which generate nonfunctional receptor variants (Kim et al. 2003; Bufe et al. 2005; Pronin et al. 2007; Dotson et al. 2008), whereas SNP-induced changes in agonist spectra of TAS2Rs have not been reported so far.”
• Genes and ligands for odorant, vomeronasal and taste receptors (2004, methodology): “Finally, classical positional cloning methods identified human TAS2R38 as the gene in a QUANTITATIVE TRAIT LOCUS that underlies taste sensitivity to phenylthiocarbamid”
• The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. (2005, neutral): “This observation, as well as the re- conducted on the hTAS2R38 constructs confirmed our earlier observations [10] that amino acid positions 49 cent finding that saccharin activates in vitro the bitterness receptors hTAS2R44 and hTAS2R43 from chromo- and 262 carry greater impact on stimulus binding a”
• A genetic variant near olfactory receptor genes influences cilantro preference (2012, background): “Genetic differences in many of these receptors are known to play a role in how we perceive tastes and smells [12-15].”
• Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology (2008, neutral): “ALDH2 null variant, which is associated with alcohol consumption (individuals who are homozygous for the allele, resulting in inefficient breakdown of acetaldehyde, have severe adverse reactions to alcohol consumption and therefore tend to drink very little) [94]; lactase-persistence variants, which”