Structure and function of the feed-forward loop network motif

By S. Mangan, Uri Alon. 2003

1,862 citations recorded by the source corpus.

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In Genetics

In Molecular Biology

Citations in the corpus

Dynamic Properties of Network Motifs Contribute to Biological Network Organization (2005, background): “…all eight possible sign combinations (describing whether interactions between nodes are positive or negative) have the same SSS, only two are abundant in the transcriptional networks of E. coli and S. cerevisiae [5], providing further evidence of a particular role for this motif in these networks.”
Network motifs: theory and experimental approaches (2007, background): “These common types are the coherent type-1 FFL (C1-FFL) and the incoherent type-1 FFL (I1-FFL”
Networks beyond pairwise interactions: structure and dynamics (2020, background): “Important examples include group interactions in both offline and online social networks [46, 593, 594], multi-authors scientific collaborations [96], network motifs in transcription networks [595] and trigenic interactions in gene regulatory networks [596], beyond pairwise mechanisms of species coe”
Network Motif Discovery Using Subgraph Enumeration and Symmetry-Breaking (2007, background): “In the past decade, new technologies have enabled the observation and study of networks of thousands and millions of nodes, such as social networks, computer networks, and, notably, biological networks, including protein-protein interaction networks [4,5,6], genetic regulatory networks [12,18], and ”
Protein networks in disease. (2008, background): “Some have argued that each type of network motif encodes a specific biological function: For instance, feed-forward loops may correspond to sign-sensitive accelerators, which speed up the response in an off-to-on direction, but not in an on-to-off direction ( Mangan and Alon 2003 ).”
Feedback for physicists: A tutorial essay on control (2005, background): “This has led to the search for “network motifs,” (Mangan and Alon, 2003; Shen-Orr et al., 2002), which are relatively simple clusters of nodes that behave as individual elements in a larger network.”
Inductive Representation Learning in Temporal Networks via Causal Anonymous Walks (2021, background): “…of a direct interaction (from node w to node u ) and an indirect interaction (from w through another node v to u ), also work as a law in the modulation of gene regulatory systems (Mangan & Alon, 2003) and also as the control principles of many engineering systems (Gorochowski et al., 2018).”
Global and Local Architecture of the Mammalian microRNA–Transcription Factor Regulatory Network (2007, background): “cerevisiae transcription network this circuit is the second most highly abundant FFL [18].”
The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks. (2003, background): “(b) Response to OFF step of Sx. (c) Delay in onset of Z promoter activity as a function of Y basal level.”
Canalization of development by microRNAs (2006, background): “FFLs are composed of two input channels, one of which regulates the other; both channels jointly regulate the expression of a third component (the target gene”
Neuronal homeostasis: time for a change? (2011, methodology): “…feedforward control has been identified as a fundamental component of gene regulation using model organisms such as yeast (Lee et al. 2002; Mangan & Alon, 2003), whilst at a somewhat higher ‘system’ level, it is an established component of motor control and is integral to the theory of…”
Scale-free networks in cell biology (2005, background): “These findings, as well as studies of the dynamical repertoire of interaction motifs, suggest that these common motifs represent elements of optimal circuit design (Csete and Doyle, 2002; Ma’ayan et al., 2005; Mangan and Alon, 2003).”
Graph theory and networks in Biology. (2006, background): “Extending the work in [26], a more complete mathematical analysis of the kinetic behaviour of the FFL motif was presented in the paper [154].”